| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MJ_0292 | tmk | MJ_0292 | MJ_0293 | Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 45.45; identified by sequence similarity; putative. | Thymidylate kinase (tmk); Similar to SP:P36590 percent identity: 31.18; identified by sequence similarity; putative. | 0.700 |
| MJ_0653 | tmk | MJ_0653 | MJ_0293 | Inosine-5'-monophosphate dehydrogenase (guaB); Similar to PID:1002715 SP:P50100 percent identity: 41.42; identified by sequence similarity; putative. | Thymidylate kinase (tmk); Similar to SP:P36590 percent identity: 31.18; identified by sequence similarity; putative. | 0.824 |
| MJ_1559 | ndk | MJ_1559 | MJ_1265 | Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency (By similarity); Belongs to the THEP1 NTPase family. | Nucleoside diphosphate kinase, (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.974 |
| MJ_1559 | tmk | MJ_1559 | MJ_0293 | Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency (By similarity); Belongs to the THEP1 NTPase family. | Thymidylate kinase (tmk); Similar to SP:P36590 percent identity: 31.18; identified by sequence similarity; putative. | 0.722 |
| coaBC | pyrH | MJ_0913 | MJ_1259 | Pantothenate metabolism flavoprotein (dfp); Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Uridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP. | 0.417 |
| coaBC | tmk | MJ_0913 | MJ_0293 | Pantothenate metabolism flavoprotein (dfp); Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Thymidylate kinase (tmk); Similar to SP:P36590 percent identity: 31.18; identified by sequence similarity; putative. | 0.739 |
| dcd | dut | MJ_0430 | MJ_1102 | Deoxycytidine triphosphate deaminase (dcd); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase with a lower affinity for dUTP than for dCTP. | Deoxycytidine triphosphate deaminase, putative (dcd); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.930 |
| dcd | ndk | MJ_0430 | MJ_1265 | Deoxycytidine triphosphate deaminase (dcd); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase with a lower affinity for dUTP than for dCTP. | Nucleoside diphosphate kinase, (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.927 |
| dcd | surE | MJ_0430 | MJ_0559 | Deoxycytidine triphosphate deaminase (dcd); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase with a lower affinity for dUTP than for dCTP. | surE stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.911 |
| dcd | thyA | MJ_0430 | MJ_0511 | Deoxycytidine triphosphate deaminase (dcd); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase with a lower affinity for dUTP than for dCTP. | Thymidylate synthase (thyA); May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.930 |
| dcd | tmk | MJ_0430 | MJ_0293 | Deoxycytidine triphosphate deaminase (dcd); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase with a lower affinity for dUTP than for dCTP. | Thymidylate kinase (tmk); Similar to SP:P36590 percent identity: 31.18; identified by sequence similarity; putative. | 0.968 |
| dut | dcd | MJ_1102 | MJ_0430 | Deoxycytidine triphosphate deaminase, putative (dcd); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Deoxycytidine triphosphate deaminase (dcd); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase with a lower affinity for dUTP than for dCTP. | 0.930 |
| dut | ndk | MJ_1102 | MJ_1265 | Deoxycytidine triphosphate deaminase, putative (dcd); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Nucleoside diphosphate kinase, (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.927 |
| dut | surE | MJ_1102 | MJ_0559 | Deoxycytidine triphosphate deaminase, putative (dcd); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | surE stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.911 |
| dut | thyA | MJ_1102 | MJ_0511 | Deoxycytidine triphosphate deaminase, putative (dcd); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase (thyA); May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.930 |
| dut | tmk | MJ_1102 | MJ_0293 | Deoxycytidine triphosphate deaminase, putative (dcd); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase (tmk); Similar to SP:P36590 percent identity: 31.18; identified by sequence similarity; putative. | 0.927 |
| ndk | MJ_1559 | MJ_1265 | MJ_1559 | Nucleoside diphosphate kinase, (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency (By similarity); Belongs to the THEP1 NTPase family. | 0.974 |
| ndk | dcd | MJ_1265 | MJ_0430 | Nucleoside diphosphate kinase, (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Deoxycytidine triphosphate deaminase (dcd); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase with a lower affinity for dUTP than for dCTP. | 0.927 |
| ndk | dut | MJ_1265 | MJ_1102 | Nucleoside diphosphate kinase, (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Deoxycytidine triphosphate deaminase, putative (dcd); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.927 |
| ndk | pyrH | MJ_1265 | MJ_1259 | Nucleoside diphosphate kinase, (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Uridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP. | 0.949 |
