STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_0294Large helicase-related protein (LHR), probably RNA helicase; Similar to GP:1707782 percent identity: 51.90; identified by sequence similarity; putative; Belongs to the helicase family. (841 aa)    
Predicted Functional Partners:
fdhD
Formate dehydrogenase (fdhD); Required for formate dehydrogenase (FDH) activity. Belongs to the FdhD family.
       0.926
MJ_0037
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 37.05; identified by sequence similarity; putative.
 
    0.833
lig
DNA ligase (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
 
    0.779
radB
DNA repair protein REC; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity).
  
 
 0.630
MJ_0296
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0296.
 
     0.628
radA
DNA repair protein RAD51 (radA); Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
  
 
 0.623
fusA
Translation elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase [...]
 
 
   0.578
rpl30
LSU ribosomal protein L30P (rpmD); Similar to SP:P14035 PID:44769 percent identity: 71.43; identified by sequence similarity; putative.
 
 
   0.572
top6B
DNA topoisomerase VI, subunit B (top6B); Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
 
 
   0.553
MJ_1417
ATP-dependent protease LA, putative (lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Degrades polypeptides processively (By similarity).
  
 
   0.551
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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