node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MJ_0406 | cmk | MJ_0406 | MJ_0656 | Ribokinase (rbsK); Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate; Belongs to the carbohydrate kinase PfkB family. | Cytidylate kinase (cmk); Similar to SP:P38493 GB:U11687 PID:533105 PID:1146214 GB:AL009126 percent identity: 33.12; identified by sequence similarity; putative. | 0.919 |
MJ_0406 | guaAA | MJ_0406 | MJ_1575 | Ribokinase (rbsK); Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate; Belongs to the carbohydrate kinase PfkB family. | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | 0.919 |
MJ_0406 | guaAB | MJ_0406 | MJ_1131 | Ribokinase (rbsK); Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate; Belongs to the carbohydrate kinase PfkB family. | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | 0.926 |
MJ_0406 | guaB | MJ_0406 | MJ_1616 | Ribokinase (rbsK); Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate; Belongs to the carbohydrate kinase PfkB family. | Inosine-5'-monophosphate dehydrogenase, (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.923 |
MJ_0406 | hisA | MJ_0406 | MJ_1532 | Ribokinase (rbsK); Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate; Belongs to the carbohydrate kinase PfkB family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA1); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 32.64; identified by sequence similarity; putative. | 0.994 |
MJ_0406 | hpt | MJ_0406 | MJ_1655 | Ribokinase (rbsK); Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate; Belongs to the carbohydrate kinase PfkB family. | Adenine phosphoribosyltransferase (apt); Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.980 |
MJ_0406 | pfkC | MJ_0406 | MJ_1604 | Ribokinase (rbsK); Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate; Belongs to the carbohydrate kinase PfkB family. | Hypothetical protein; Catalyzes the phosphorylation of fructose 6-phosphate and D- glucose to fructose 1,6-bisphosphate and D-glucose 6-phosphate, respectively, using ADP as the phosphate donor; Belongs to the carbohydrate kinase PfkC family. | 0.894 |
MJ_0406 | purA | MJ_0406 | MJ_0561 | Ribokinase (rbsK); Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate; Belongs to the carbohydrate kinase PfkB family. | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.982 |
MJ_0406 | purO | MJ_0406 | MJ_0626 | Ribokinase (rbsK); Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate; Belongs to the carbohydrate kinase PfkB family. | Conserved hypothetical protein; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP; Belongs to the archaeal IMP cyclohydrolase family. | 0.902 |
MJ_0406 | surE | MJ_0406 | MJ_0559 | Ribokinase (rbsK); Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate; Belongs to the carbohydrate kinase PfkB family. | surE stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.906 |
cmk | MJ_0406 | MJ_0656 | MJ_0406 | Cytidylate kinase (cmk); Similar to SP:P38493 GB:U11687 PID:533105 PID:1146214 GB:AL009126 percent identity: 33.12; identified by sequence similarity; putative. | Ribokinase (rbsK); Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate; Belongs to the carbohydrate kinase PfkB family. | 0.919 |
cmk | purA | MJ_0656 | MJ_0561 | Cytidylate kinase (cmk); Similar to SP:P38493 GB:U11687 PID:533105 PID:1146214 GB:AL009126 percent identity: 33.12; identified by sequence similarity; putative. | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.691 |
cmk | surE | MJ_0656 | MJ_0559 | Cytidylate kinase (cmk); Similar to SP:P38493 GB:U11687 PID:533105 PID:1146214 GB:AL009126 percent identity: 33.12; identified by sequence similarity; putative. | surE stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
guaAA | MJ_0406 | MJ_1575 | MJ_0406 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Ribokinase (rbsK); Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate; Belongs to the carbohydrate kinase PfkB family. | 0.919 |
guaAA | guaAB | MJ_1575 | MJ_1131 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | 0.998 |
guaAA | guaB | MJ_1575 | MJ_1616 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase, (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.993 |
guaAA | hisA | MJ_1575 | MJ_1532 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA1); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 32.64; identified by sequence similarity; putative. | 0.618 |
guaAA | hpt | MJ_1575 | MJ_1655 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase (apt); Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.979 |
guaAA | purA | MJ_1575 | MJ_0561 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.914 |
guaAA | surE | MJ_1575 | MJ_0559 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | surE stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.957 |