node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MJ_0409 | MJ_0410 | MJ_0409 | MJ_0410 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0409. | Hypothetical protein; Similar to PID:1174351 percent identity: 32.34; identified by sequence similarity; putative. | 0.930 |
MJ_0409 | hisF | MJ_0409 | MJ_0411 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0409. | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.871 |
MJ_0409 | mptD | MJ_0409 | MJ_0408 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0409. | Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). | 0.907 |
MJ_0409 | nadA | MJ_0409 | MJ_0407 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0409. | Quinolinate synthetase (nadA); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.839 |
MJ_0410 | MJ_0409 | MJ_0410 | MJ_0409 | Hypothetical protein; Similar to PID:1174351 percent identity: 32.34; identified by sequence similarity; putative. | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0409. | 0.930 |
MJ_0410 | hisF | MJ_0410 | MJ_0411 | Hypothetical protein; Similar to PID:1174351 percent identity: 32.34; identified by sequence similarity; putative. | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.925 |
MJ_0410 | mptD | MJ_0410 | MJ_0408 | Hypothetical protein; Similar to PID:1174351 percent identity: 32.34; identified by sequence similarity; putative. | Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). | 0.778 |
MJ_0410 | nadA | MJ_0410 | MJ_0407 | Hypothetical protein; Similar to PID:1174351 percent identity: 32.34; identified by sequence similarity; putative. | Quinolinate synthetase (nadA); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.806 |
MJ_1427 | cofE | MJ_1427 | MJ_0768 | Hypothetical protein; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). | Conserved hypothetical protein; Catalyzes the GTP-dependent successive addition of two L- glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy- 5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. Cannot use F420-2 as substrate to add more glutamates. Exhibits maximum activity with GTP, compared with UTP (66%) and dGTP (25%); with ATP, only F420-1 is observed as the product; CTP and TTP support no activity. Belongs to the CofE family. | 0.709 |
MJ_1427 | mptD | MJ_1427 | MJ_0408 | Hypothetical protein; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). | Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). | 0.732 |
cofE | MJ_1427 | MJ_0768 | MJ_1427 | Conserved hypothetical protein; Catalyzes the GTP-dependent successive addition of two L- glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy- 5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. Cannot use F420-2 as substrate to add more glutamates. Exhibits maximum activity with GTP, compared with UTP (66%) and dGTP (25%); with ATP, only F420-1 is observed as the product; CTP and TTP support no activity. Belongs to the CofE family. | Hypothetical protein; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). | 0.709 |
cofE | mptD | MJ_0768 | MJ_0408 | Conserved hypothetical protein; Catalyzes the GTP-dependent successive addition of two L- glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy- 5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. Cannot use F420-2 as substrate to add more glutamates. Exhibits maximum activity with GTP, compared with UTP (66%) and dGTP (25%); with ATP, only F420-1 is observed as the product; CTP and TTP support no activity. Belongs to the CofE family. | Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). | 0.753 |
hisF | MJ_0409 | MJ_0411 | MJ_0409 | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0409. | 0.871 |
hisF | MJ_0410 | MJ_0411 | MJ_0410 | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | Hypothetical protein; Similar to PID:1174351 percent identity: 32.34; identified by sequence similarity; putative. | 0.925 |
hisF | mptD | MJ_0411 | MJ_0408 | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). | 0.739 |
hisF | nadA | MJ_0411 | MJ_0407 | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | Quinolinate synthetase (nadA); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.783 |
hisF | purB | MJ_0411 | MJ_0929 | Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | Adenylosuccinate lyase (purB); Similar to GB:J02732 SP:P12047 PID:143366 GB:AL009126 percent identity: 42.51; identified by sequence similarity; putative. | 0.831 |
mptA | mptB | MJ_0775 | MJ_0837 | Conserved hypothetical protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. It is also able to utilize a variety of GTP analogs as substrates, including GDP, beta,gamma-methylene-GTP and GTP-[gamma- thio]; Belongs to the GTP cyclohydrolase IV family. | Cmp-binding-factor 1 isolog; Cyclic phosphodiesterase that hydrolyzes the cyclic phosphate of 7,8-dihydroneopterin 2',3'-cyclic phosphate (H2N-cP) and converts it to a mixture of 7,8-dihydroneopterin 2'-phosphate (H2N-2'P) and 7,8- dihydroneopterin 3'-phosphate (H2N-3'P). Is also able to utilize other phosphodiesters as substrates in vitro: hydrolysis of bis-pNPP and pNPPC produces nitrophenyl phosphate, and that of 2',3'-cAMP produces 3'-AMP. ATP, 3',5'-cAMP, GTP, 3',5'-cGMP, and 4',5'-cFMN cannot serve as substrates. | 0.935 |
mptA | mptD | MJ_0775 | MJ_0408 | Conserved hypothetical protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. It is also able to utilize a variety of GTP analogs as substrates, including GDP, beta,gamma-methylene-GTP and GTP-[gamma- thio]; Belongs to the GTP cyclohydrolase IV family. | Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). | 0.629 |
mptA | mptE | MJ_0775 | MJ_1634 | Conserved hypothetical protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. It is also able to utilize a variety of GTP analogs as substrates, including GDP, beta,gamma-methylene-GTP and GTP-[gamma- thio]; Belongs to the GTP cyclohydrolase IV family. | Conserved hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. | 0.652 |