STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_0449Hypothetical transmembrane protein yeaB; Similar to GP:1708640 percent identity: 31.05; identified by sequence similarity; putative. (283 aa)    
Predicted Functional Partners:
mdh
L-lactate dehydrogenase EGAD|7256|705; Catalyzes the reversible oxidation of (S)-malate and (S)- sulfolactate to oxaloacetate and sulfopyruvate, respectively. Can use both NADH and NADPH, although activity is higher with NADPH. Oxidation of (S)-sulfolactate is observed only in the presence of NADP(+). Can also oxidize tartrate. Cannot reduce pyruvate, nor alpha-ketoglutarate. Belongs to the LDH/MDH superfamily.
  
    0.978
MJ_0448
Conserved hypothetical protein; Similar to PID:577190 percent identity: 29.38; identified by sequence similarity; putative; Belongs to the metallo-beta-lactamase superfamily.
  
    0.952
MJ_1036
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1036.
  
  
 0.712
tgtA
Queuine tRNA-ribosyltransferase (tgtA); Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. Can also utilize guanine as substrate.
       0.575
MJ_0447
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0447.
       0.568
MJ_1163
Conserved hypothetical protein; Similar to GP:1707795 percent identity: 42.53; identified by sequence similarity; putative; Belongs to the UPF0173 family.
  
  
 0.530
MJ_0566
Ferrous iron transport protein B (feoB); Probable transporter of a GTP-driven Fe(2+) uptake system, might be able to transport Fe(2+) into or out of the cell (Probable). Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
     
 0.494
sla
S-layer structural protein; S-layer protein. The S-layer is a paracrystalline mono- layered assembly of proteins which coat the surface of the cell. Belongs to the Mj S-layer protein family.
   
    0.463
glnA
Glutamine synthetase (glnA); Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Beta-glutamate is a much poorer substrate than alpha-glutamate.
  
  
 0.463
MJ_1388
Adenosylhomocysteinase (ahcY); Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine. Is specific for SIH and inosine as it is unable to either hydrolyze SAH or synthesize SAH from adenosine and Hcy. Belongs to the adenosylhomocysteinase family.
  
    0.459
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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