STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
secYProtein translocase, subunit SEC61 alpha (secY); The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (436 aa)    
Predicted Functional Partners:
secE
Protein translocase, subunit SEC61 gamma (secE); Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
   
 
 0.994
adkA
Adenylate kinase (adk); Similar to PID:1086550 PID:1591182 percent identity: 100.00; identified by sequence similarity; putative; Belongs to the archaeal adenylate kinase family.
 
  
 0.980
ftsY
Signal recognition particle, receptor; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
  
 
 0.977
rpl15
LSU ribosomal protein L15P (rplO); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
 
  
 0.967
rpl30
LSU ribosomal protein L30P (rpmD); Similar to SP:P14035 PID:44769 percent identity: 71.43; identified by sequence similarity; putative.
 
    0.966
rpl32e
LSU ribosomal protein L32E; Similar to SP:P14549 PID:44765 percent identity: 56.82; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eL32 family.
 
  
 0.963
rpl19e
LSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family.
 
  
 0.958
rpl6
LSU ribosomal protein L6P (rplF); This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
 
  
 0.953
rps5
SSU ribosomal protein S5P (rpsE); With S4 and S12 plays an important role in translational accuracy.
 
    0.947
rpl18
LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
 
    0.940
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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