Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nadCNicotinate-nucleotide pyrophosphorylase (nadC); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (283 aa)    
Predicted Functional Partners:
nadA
Quinolinate synthetase (nadA); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
 
 0.999
MJ_0541
Conserved hypothetical protein; Similar to GP:1001812 percent identity: 32.62; identified by sequence similarity; putative; Belongs to the archaeal NMN adenylyltransferase family.
    
 0.970
MJ_0033
Succinate dehydrogenase, flavoprotein subunit (sdhA); Similar to GP:1524302 percent identity: 41.63; identified by sequence similarity; putative.
   
 0.944
surE
surE stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.910
nadX
Conserved hypothetical protein; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
  
  
 0.907
nadE
NH(3)-dependent NAD+ synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
     
 0.726
argC
N-acetyl-gamma-glutamyl-phosphate reductase (argC); Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
      0.699
MJ_0492
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0492.
       0.693
ribH
Riboflavin synthase beta chain (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.
  
  
 0.656
argB
Acetylglutamate kinase (argB); Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
      0.611
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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