STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_0498Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 38.41; identified by sequence similarity; putative. (156 aa)    
Predicted Functional Partners:
hjc
Hypothetical protein; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family.
  
    0.960
leuC
3-isopropylmalate dehydratase (leuC); Enzyme with broad specificity that catalyzes reversible hydroxyacid isomerizations via dehydration/hydration reactions. Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate, a step involved in leucine biosynthesis. Catalyzes the isomerization between 2-methylmalate and 3-methylmalate, via the formation of 2-methylmaleate (citraconate), a step involved in isoleucine biosynthesis. Also displays malease activity, i.e. catalyzes the hydration of maleate to form (R)-malate; Belongs to the [...]
       0.489
MJ_1412
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 37.85; identified by sequence similarity; putative; Belongs to the UPF0288 family.
  
    0.476
MJ_0094
Methyl coenzyme M reductase II, operon protein C (mtrC); Similar to GB:M16893 SP:P07960 PID:150057 percent identity: 31.15; identified by sequence similarity; putative.
       0.431
MJ_0404
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 65.03; identified by sequence similarity; putative.
       0.431
MJ_0800
(R)-2-hydroxyglutaryl-CoA dehydratase activator; Similar to SP:P11568 GB:X59645 PID:433932 percent identity: 31.78; identified by sequence similarity; putative.
       0.431
MJ_0802
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 32.96; identified by sequence similarity; putative.
       0.431
MJ_1242
Methyl coenzyme M reductase system, component A2 (atwA); Similar to GB:L11748 PID:293151 PID:385924 GB:AE000666 percent identity: 60.26; identified by sequence similarity; putative; Belongs to the ABC transporter superfamily.
       0.431
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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