| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| guaAA | guaAB | MJ_1575 | MJ_1131 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | 0.998 |
| guaAA | guaB | MJ_1575 | MJ_1616 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase, (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.993 |
| guaAA | hpt | MJ_1575 | MJ_1655 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase (apt); Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.979 |
| guaAA | purA | MJ_1575 | MJ_0561 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.914 |
| guaAA | purB | MJ_1575 | MJ_0929 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase (purB); Similar to GB:J02732 SP:P12047 PID:143366 GB:AL009126 percent identity: 42.51; identified by sequence similarity; putative. | 0.859 |
| guaAA | pyrF | MJ_1575 | MJ_0252 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.606 |
| guaAA | pyrH | MJ_1575 | MJ_1259 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Uridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP. | 0.755 |
| guaAA | surE | MJ_1575 | MJ_0559 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | surE stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.957 |
| guaAB | guaAA | MJ_1131 | MJ_1575 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | 0.998 |
| guaAB | guaB | MJ_1131 | MJ_1616 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase, (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaAB | hpt | MJ_1131 | MJ_1655 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase (apt); Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.992 |
| guaAB | purA | MJ_1131 | MJ_0561 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.810 |
| guaAB | purB | MJ_1131 | MJ_0929 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase (purB); Similar to GB:J02732 SP:P12047 PID:143366 GB:AL009126 percent identity: 42.51; identified by sequence similarity; putative. | 0.955 |
| guaAB | pyrF | MJ_1131 | MJ_0252 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.658 |
| guaAB | pyrH | MJ_1131 | MJ_1259 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | Uridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP. | 0.682 |
| guaAB | surE | MJ_1131 | MJ_0559 | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | surE stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.958 |
| guaB | guaAA | MJ_1616 | MJ_1575 | Inosine-5'-monophosphate dehydrogenase, (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | 0.993 |
| guaB | guaAB | MJ_1616 | MJ_1131 | Inosine-5'-monophosphate dehydrogenase, (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | hpt | MJ_1616 | MJ_1655 | Inosine-5'-monophosphate dehydrogenase, (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenine phosphoribosyltransferase (apt); Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.675 |
| guaB | purA | MJ_1616 | MJ_0561 | Inosine-5'-monophosphate dehydrogenase, (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.998 |