STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_0577Conserved hypothetical protein; Similar to SP:P42297 PID:603780 PID:849027 GB:AL009126 percent identity: 31.54; identified by sequence similarity; putative. (162 aa)    
Predicted Functional Partners:
MJ_0226
Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house- cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on GTP or dGTP, both of which are hydrolyzed more than 100-fold less efficiently than X [...]
     
 0.846
MJ_0576
Malic acid transport protein; Similar to SP:P50537 percent identity: 23.78; identified by sequence similarity; putative.
  
  
 0.803
pstA
Phosphate transport system permease protein A (pstA); Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
     
 0.727
MJ_1362
NADH ubiquinone oxidoreductase, subunit 1 isolog; Similar to SP:P03887 percent identity: 24.02; identified by sequence similarity; putative.
     
 0.713
nep1
Conserved hypothetical protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of pseudouridine at position 914 (Psi914) in 16S rRNA. Is not able to methylate uridine at this position.
     
 0.704
nifH
Nitrogenase iron protein (nifH); The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
  
  
 0.676
MJ_1158
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1158.
   
    0.532
MJ_0575
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 36.11; identified by sequence similarity; putative; To M.jannaschii MJ0838.
       0.522
ogt
methylated-DNA-protein-cysteine methyltransferase, putative (ogt); Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
  
    0.517
MJ_0574
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0574.
       0.511
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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