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thi4 protein (Methanocaldococcus jannaschii) - STRING interaction network
"thi4" - Thiamine thiazole synthase in Methanocaldococcus jannaschii
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Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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thi4Thiamine thiazole synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur (267 aa)    
Predicted Functional Partners:
MJ1130
Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction (By similarity). The Bud32 domain probably displays kinase activity that regulates Kae1 function. In vitro, exhibits low ATPase activi [...] (535 aa)
              0.999
MJ0122
Ribose 1,5-bisphosphate isomerase; Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO (By similarity); Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily (308 aa)
           
  0.938
MJ0667
AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO; Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily (503 aa)
         
  0.924
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (176 aa)
         
  0.861
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB-J02732 SP-P12043 PID-143371 GB-AL009126 percent identity- 39.76; identified by sequence similarity; putative (350 aa)
   
     
  0.742
thiDN
Bifunctional thiamine biosynthesis protein ThiDN; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P; In the C-terminal section; belongs to the ThiN family (421 aa)
 
   
  0.706
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction; Belongs to the ThiC family (438 aa)
   
   
  0.645
MJ1181
Uncharacterized protein MJ1181; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1181 (199 aa)
     
   
  0.571
MJ1180
Uncharacterized protein MJ1180; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1180 (145 aa)
     
   
  0.571
rps24e
30S ribosomal protein S24e; Similar to SP-P19953 GB-X70117 PID-312779 percent identity- 42.57; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eS24 family (101 aa)
              0.565
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii DSM2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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