STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLGlutamate-1-semialdehyde aminotransferase (hemL); Similar to GB:M57676 SP:P30949 PID:143040 GB:AL009126 percent identity: 51.67; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (445 aa)    
Predicted Functional Partners:
hemA
glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.994
hemB
Porphobilinogen synthase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
 
 
 0.993
hemC
Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.955
MJ_1063
Spore coat polysaccharide biosynthesis protein F (spsF); Similar to GB:X73124 SP:P39626 PID:413992 GB:AL009126 percent identity: 38.94; identified by sequence similarity; putative.
      0.940
fbp
Conserved hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
      
 0.873
MJ_0606
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 32.18; identified by sequence similarity; putative.
  
    0.838
hemD
Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
  
 0.794
MJ_0604
Conserved hypothetical protein; Similar to PID:1652091 percent identity: 30.12; identified by sequence similarity; putative; Belongs to the M.jannaschii MJ0126/MJ0128/MJ0141/MJ0435/MJ0604/MJ1215/MJ1217/MJ1305/MJ1379 family.
       0.762
MJ_0605
Hypothetical protein; Brute force ORF; identified by GeneMark; putative; M. jannaschii predicted coding region MJ0605; Belongs to the UPF0332 family.
       0.762
MJ_0607
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0607.
       0.759
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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