STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spcSConserved hypothetical protein; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. (434 aa)    
Predicted Functional Partners:
pstK
Yeast KTI12 Protein; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.
  
  
 0.996
MJ_0158
Selenocystein synthase (selA); Similar to SP:P23328 GB:M64177 PID:147804 PID:466729 GB:U00096 percent identity: 34.65; identified by sequence similarity; putative; Belongs to the UPF0425 family.
     
 0.977
MJ_1678
Acetyltransferase; Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L- cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
  
   
 0.892
selB
Putative translation factor, EF-1 alpha family; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.
 
   
 0.881
MJ_0609
Amino acid transporter; Similar to GB:X77502 GB:X92657 PID:1890309 PID:608675 percent identity: 21.96; identified by sequence similarity; putative.
     
 0.772
serS
seryl-tRNA synthetase (serS); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
      
 0.722
MJ_0611
Conserved hypothetical integral membrane protein; Similar to GP:1565238 percent identity: 34.56; identified by sequence similarity; putative; Belongs to the peptidase M50B family.
       0.573
ppaC
Exopolyphosphatase (ppx1); Similar to SP:P38698 PID:453695 PID:458943 percent identity: 27.80; identified by sequence similarity; putative; Belongs to the PPase class C family.
       0.470
pus10
Conserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
  
     0.409
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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