Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MJ_0619Conserved hypothetical protein; Is responsible for the addition of methyl groups at C-7 and C-9 of the pterin ring during methanopterin (MPT) biosynthesis. Catalyzes methylation of 7,8-dihydro-6-hydroxymethylpterin, likely using methylenetetrahydromethanopterin as a methyl group donor, via a radical-based mechanism. (506 aa)    
Predicted Functional Partners:
MJ_0618
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 41.76; identified by sequence similarity; putative; Belongs to the UPF0235 family.
       0.956
carS
Conserved hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.
 
     0.725
mptN
Ribosomal protein S6 modification protein 1 (rimK); Catalyzes the ATP or GTP-dependent addition of one L- glutamate molecule to tetrahydromethanopterin, producing tetrahydrosarcinapterin.
 
     0.659
MJ_1419
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 42.42; identified by sequence similarity; putative; Belongs to the UPF0147 family.
  
     0.487
MJ_1623
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1623.
     
 0.471
MJ_0532
Bacteriochlorophyll synthase 43 kDa subunit (chlP); Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
     
 0.445
pyrE
Orotate phosphoribosyl transferase (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
       0.423
MJ_0038
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 51.12; identified by sequence similarity; putative.
  
     0.415
rps8e
SSU ribosomal protein S8E; Similar to SP:P49402 percent identity: 50.00; identified by sequence similarity; putative.
  
     0.403
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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