Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MJ_0631Hydrogenase maturation protease (hycI); Identified by sequence similarity; putative; Belongs to the peptidase A31 family. (169 aa)    
Predicted Functional Partners:
MJ_0630
Putative phosphate permease; Potential transporter for phosphate; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
       0.948
leuS
leucyl-tRNA synthetase (leuS); Similar to SP:P26637 PID:1370340 PID:1403549 PID:3508 percent identity: 35.17; identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
   0.853
hypF
Hydrogenase expression regulatory protein (hypF); Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.796
hypA
Hydrogenase expression/formation protein (hypA); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.781
MJ_0632
Replication initiator protein, putative (dnaA); Similar to SP:P35892 PID:416273 percent identity: 30.26; identified by sequence similarity; putative; Belongs to the archaeal ATPase family.
       0.727
MJ_0629
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 29.21; identified by sequence similarity; putative; Belongs to the UPF0111 family.
       0.715
MJ_0627
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0627.
       0.709
MJ_0628
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0628; To M.jannaschii MJ0992.
       0.709
MJ_1417
ATP-dependent protease LA, putative (lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Degrades polypeptides processively (By similarity).
       0.706
MJ_0283
Nucleotide-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
     
 0.688
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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