Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MJ_0636Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative. (397 aa)    
Predicted Functional Partners:
prs
Ribose-phosphate pyrophosphokinase, (prsA); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). It can also use dATP as diphosphoryl donor.
 
 0.975
glyA
Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. The use of tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate is 450-fold less efficient than that of H4MPT. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine and L-threo- beta-phenylserine; Belongs to the SHMT family.
 
 
 0.967
thyA
Thymidylate synthase (thyA); May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
 
 
 0.935
trx
Thioredoxin (trx); Acts to maintain redox homeostasis; functions as a protein disulfide reductase.
  
 0.923
MJ_0581
Conserved hypothetical protein; Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase (By similarity). Has low thioredoxin activity in vitro (By similarity).
  
 0.923
porA
Pyruvate ferredoxin oxidoreductase, subunit alpha (porA); Similar to PID:1197363 percent identity: 57.33; identified by sequence similarity; putative.
  
 
 0.919
korA
2-ketoglutarate ferredoxin oxidoreductase, subunit alpha (korA); Similar to GB:X64521 PID:43498 percent identity: 44.24; identified by sequence similarity; putative.
  
 
 0.919
korB
2-ketoglutarate ferredoxin oxidoreductase, subunit beta (korB); Similar to GB:X64521 PID:43499 percent identity: 40.43; identified by sequence similarity; putative.
    
 0.919
porC
Pyruvate ferredoxin oxidoreductase, subunit gamma (porG); Similar to PID:1197358 percent identity: 63.22; identified by sequence similarity; putative.
    
 0.917
korC
2-ketoglutarate ferredoxin oxidoreductase, subunit gamma (korG); Similar to PID:1197358 percent identity: 32.00; identified by sequence similarity; putative.
    
 0.917
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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