Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rpl14eLSU ribosomal protein L14E; Similar to SP:P36105 SP:P38754 PID:2131109 PID:485979 PID:500817 percent identity: 36.36; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eL14 family. (80 aa)    
Predicted Functional Partners:
rpl22
LSU ribosomal protein L22P (rplV); This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
  
 0.999
rpl6
LSU ribosomal protein L6P (rplF); This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
  
 0.999
rpl18
LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
 
 0.999
rpl34e
LSU ribosomal protein L34E; Similar to GB:L38941 SP:P49207 PID:1008856 percent identity: 36.59; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eL34 family.
 
 0.999
rpl30e
LSU ribosomal protein L30E; Similar to SP:P14025 GB:X15970 PID:44782 percent identity: 64.71; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eL30 family.
 
 0.999
rpl3
LSU ribosomal protein L3P (rplC); One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
  
 0.998
rpl23
LSU ribosomal protein L23P (rplW); Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family.
  
 0.998
rpl29
LSU ribosomal protein L29P (rpmC); Similar to SP:P22665 PID:2425183 percent identity: 51.56; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uL29 family.
  
 0.998
rpl24
LSU ribosomal protein L24P (rplX); One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
 
 0.998
rpl5
LSU ribosomal protein L5P (rplE); This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
  
 0.998
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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