STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_0663Acetolactate synthase large subunit (ilvB); Similar to GB:L10328 SP:P08142 GB:J01633 GB:X02541 PID:146455 percent identity: 30.21; identified by sequence similarity; putative; Belongs to the TPP enzyme family. (494 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase small subunit (ilvN); Similar to GB:L03181 SP:P37252 PID:143092 PID:1770067 GB:AL009126 percent identity: 49.37; identified by sequence similarity; putative; Belongs to the acetolactate synthase small subunit family.
 0.997
ilvC
Ketol-acid reductoisomerase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.981
leuB
3-isopropylmalate dehydrogenase 1 (leuB1); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate, which decarboxylates to 4-methyl-2-oxopentanoate (2- oxoisocaproate). Also catalyzes the oxidative decarboxylation of 3- methylmalate to 2-oxobutyrate, and that of D-malate to pyruvate. Cannot use NADP(+) instead of NAD(+). Cannot catalyze the oxidation of L- malate, L-tartrate, D-tartrate, DL-isocitrate, or DL-lactate.
 
 0.949
cimA
2-isopropylmalate synthase (leuA); Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.946
ilvB
Acetolactate synthase large subunit (ilvB); Similar to GB:L03181 SP:P37251 PID:143091 percent identity: 50.18; identified by sequence similarity; putative; Belongs to the TPP enzyme family.
  
  
0.933
MJ_0664
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0664.
  
  
 0.928
porA
Pyruvate ferredoxin oxidoreductase, subunit alpha (porA); Similar to PID:1197363 percent identity: 57.33; identified by sequence similarity; putative.
  
 
 0.921
korA
2-ketoglutarate ferredoxin oxidoreductase, subunit alpha (korA); Similar to GB:X64521 PID:43498 percent identity: 44.24; identified by sequence similarity; putative.
  
 
 0.921
porB
Pyruvate ferredoxin oxidoreductase, subunit beta (porB); Similar to PID:1197364 percent identity: 58.89; identified by sequence similarity; putative.
  
 
 0.920
porC
Pyruvate ferredoxin oxidoreductase, subunit gamma (porG); Similar to PID:1197358 percent identity: 63.22; identified by sequence similarity; putative.
  
 
 0.920
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.