STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
arfCRiboflavin-specific deaminase (ribG); Catalyzes an early step in riboflavin biosynthesis, the NAD(P)H-dependent reduction of the ribose side chain of 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6- ribitylamino-4(3H)-pyrimidinone 5'-phosphate. The beta anomer is the authentic substrate, and the alpha anomer can serve as substrate subsequent to spontaneous anomerization. NADPH and NADH function equally well as the reductants. Does not catalyze the reduction of 5- amino-6-(5-phospho-D-ribosylamino)uracil to 5-amino-6-(5-phospho-D- ribitylamino)uracil; [...] (224 aa)    
Predicted Functional Partners:
ribB
GTP cyclohydrolase II (ribA); Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
 
 
 0.964
ribH
Riboflavin synthase beta chain (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.
 
 
 0.953
arfB
Conserved hypothetical protein; Catalyzes the hydrolysis of the formamide of 2-amino-5- formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy); Belongs to the creatininase superfamily. FAPy deformylase family.
    
 0.941
MJ_1624
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 37.50; identified by sequence similarity; putative.
      0.892
MJ_0670
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 37.37; identified by sequence similarity; putative.
       0.779
prf1
Peptide chain release factor aRF, subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
   
   0.753
MJ_0198
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0198.
   
 
 0.709
eno
Enolase (eno); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
   
 
 0.709
MJ_0699
Atrazine chlorohydrolase isolog; Similar to GP:1493840 percent identity: 28.15; identified by sequence similarity; putative; Belongs to the metallo-dependent hydrolases superfamily.
     
 0.688
MJ_0669
ATP-dependent RNA helicase, DEAD-family (deaD); Similar to GB:L42023 SP:P44586 PID:1003361 PID:1222156 PID:1204489 percent identity: 43.17; identified by sequence similarity; putative; Belongs to the DEAD box helicase family.
   
 
 0.636
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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