STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MJ_0699Atrazine chlorohydrolase isolog; Similar to GP:1493840 percent identity: 28.15; identified by sequence similarity; putative; Belongs to the metallo-dependent hydrolases superfamily. (380 aa)    
Predicted Functional Partners:
MJ_1154
Conserved hypothetical protein; Similar to GP:1561567 percent identity: 32.98; identified by sequence similarity; putative.
     
 0.708
dadD
N-ethylammeline chlorohydrolase (trzA); Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereup [...]
 
     0.708
glyS
glycyl-tRNA synthetase (glyS); Catalyzes the attachment of glycine to tRNA(Gly).
  
    0.703
MJ_0531
Conserved hypothetical protein; Similar to SP:P42297 PID:603780 PID:849027 GB:AL009126 percent identity: 37.76; identified by sequence similarity; putative; Belongs to the universal stress protein A family.
     
 0.690
arfC
Riboflavin-specific deaminase (ribG); Catalyzes an early step in riboflavin biosynthesis, the NAD(P)H-dependent reduction of the ribose side chain of 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6- ribitylamino-4(3H)-pyrimidinone 5'-phosphate. The beta anomer is the authentic substrate, and the alpha anomer can serve as substrate subsequent to spontaneous anomerization. NADPH and NADH function equally well as the reductants. Does not catalyze the reduction of 5- amino-6-(5-phospho-D-ribosylamino)uracil to 5-amino-6-(5-phospho-D- ribitylamino)uracil; [...]
     
 0.688
ribC
Riboflavin synthase (ribC); Similar to GP:1419079 percent identity: 68.00; identified by sequence similarity; putative; Belongs to the DMRL synthase family.
 
     0.645
MJ_0700
Conserved hypothetical protein; Similar to SP:P11666 PID:41424 PID:882453 GB:U00096 PID:1789291 percent identity: 22.34; identified by sequence similarity; putative.
     
 0.605
priL
Hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
  
    0.595
ribH
Riboflavin synthase beta chain (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.
  
    0.591
polB
DNA polymerase delta small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity); Belongs to the DNA polymerase delta/II small subunit family.
     
 0.586
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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