Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cooSCarbon monoxide dehydrogenase, catalytic subunit (cooS); CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH). (624 aa)    
Predicted Functional Partners:
cdhD
acetyl-CoA decarbonylase/synthase, subunit delta (cdhD); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family.
 
  
 0.959
cdhA
acetyl-CoA decarbonylase/synthase, subunit alpha (cdhA); Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
     
 0.955
cdhE
acetyl-CoA decarbonylase/synthase, subunit gamma (cdhE); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).
  
  
 0.944
MJ_0823
CODH nickel-insertion accessory protein CooC (cooC); Similar to GP:1498749 percent identity: 45.65; identified by sequence similarity; putative; To M.jannaschii MJ0084 and MJ0685.
 
   
 0.929
MJ_0265
Carbon monoxide dehydrogenase, iron sulfur subunit CooF-1 (cooF2); Similar to GB:M90421 SP:P31894 PID:1171263 PID:1498747 percent identity: 39.10; identified by sequence similarity; putative.
    
 0.922
MJ_0264
Carbon monoxide dehydrogenase, iron sulfur subunit CooF-1 (cooF1); Similar to GB:M90421 SP:P31894 PID:1171263 PID:1498747 percent identity: 36.04; identified by sequence similarity; putative.
    
 0.912
MJ_0006
Formate dehydrogenase, alpha subunit; Similar to GB:J02581 SP:P06131 PID:149708 percent identity: 41.56; identified by sequence similarity; putative; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
    
 0.910
cdhB
acetyl-CoA decarbonylase/synthase, subunit epsilon (cdhB); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. Belongs to the CdhB family.
     
 0.904
porC
Pyruvate ferredoxin oxidoreductase, subunit gamma (porG); Similar to PID:1197358 percent identity: 63.22; identified by sequence similarity; putative.
     
 0.903
fdhB
Formate dehydrogenase, beta subunit; Catalyzes the oxidation of formate; Belongs to the FrhB family.
    
  0.902
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.