STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fprAFlavoprotein (fpaA); Probably functions as an electron acceptor for a hydrogenase; however there is an uncharacterized intermediate between the hydrogenase and flavoprotein A; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family. (416 aa)    
Predicted Functional Partners:
MJ_0649
NADH oxidase (nox); Catalyzes the four-electron reduction of molecular oxygen to water.
    
 0.918
MJ_0747
Hemerythrin sipunculid; Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen- binding site contains two iron atoms; Belongs to the hemerythrin family.
  
  
 0.749
fsr
Coenzyme F420-reducing hydrogenase, beta subunit (frhB); Catalyzes the reduction of sulfite to sulfide using reduced F420 as the electron source. Involved in sulfite detoxification and assimilation. Cannot use NADH or NADPH; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
     
 0.734
hmgA
3-hydroxy-3-methylglutaryl coenzyme A reductase; Converts HMG-CoA to mevalonate.
      
 0.665
glnA
Glutamine synthetase (glnA); Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Beta-glutamate is a much poorer substrate than alpha-glutamate.
     
 0.664
MJ_0741
Desulfoferrodoxin, putative (rbo); Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.
  
  
 0.649
MJ_0746
Conserved hypothetical protein; Similar to PID:710357 GB:AE000666 percent identity: 70.59; identified by sequence similarity; putative.
  
  
 0.542
MJ_0749
Conserved hypothetical protein; Similar to GP:1787226 percent identity: 31.17; identified by sequence similarity; putative.
  
  
 0.529
MJ_0750
Ferredoxin-type protein (napH); Similar to SP:P33934 PID:405929 GB:U00096 PID:1788532 percent identity: 25.27; identified by sequence similarity; putative.
  
  
 0.428
MJ_0735
Rubredoxin 1 (rd1); Rubredoxin is a small nonheme, iron protein lacking acid- labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule (By similarity).
 
  
 0.427
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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