STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mfnDConserved hypothetical protein; Catalyzes the formation of an amide bond between tyramine and the gamma carboxy group of L-glutamate. The enzyme also accepts phenylethylamine in vitro. (308 aa)    
Predicted Functional Partners:
mfnF
Conserved hypothetical protein; Catalyzes the condensation between 5-(aminomethyl)-3- furanmethanol diphosphate (F1-PP) and gamma-glutamyltyramine to produce APMF-Glu.
 
  
 0.996
mfnA
Group II decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.
 
  
 0.986
mfnE
Delta 1-pyrroline-5-carboxylate synthetase; Catalyzes the formation of 5-(aminomethyl)-3-furanmethanol diphosphate (F1-PP) from 5-(aminomethyl)-3-furanmethanol phosphate (F1- P) and ATP. In vitro, can also act as an adenylate kinase that catalyzes the transfer of a phosphoryl group from ATP to AMP, generating two molecules of ADP.
 
   
 0.962
dys
Deoxyhypusine synthase (dys1); Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
       0.943
mfnB
Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
 
   
 0.928
MJ_0107
Dihydropteroate synthase; Unknown. Does not possess dihydropteroate synthase (DHPS) activity since it does not catalyze the condensation of 6- hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) and 4- aminobenzoate to form 7,8-dihydropteroate.
  
   
 0.898
MJ_0816
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0816.
       0.860
mfnC
Aspartate aminotransferase (aspB2); Catalyzes the transamination reaction between 4- (hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) and alanine to produce pyruvate and 5-(aminomethyl)-3-furanmethanol phosphate (F1- P), the precursor for the furan moiety in methanofuran. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
      
 0.785
cbiH
Cobalamin biosynthesis precorrin-3 methylase (cbiH); Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity).
       0.759
fwdA
Formylmethanofuran dehydrogenase, subunit A (tungsten) (fwdA); Similar to PID:871462 GB:AE000666 PID:1890210 percent identity: 68.95; identified by sequence similarity; putative; Belongs to the metallo-dependent hydrolases superfamily. FwdA/FmdA family.
 
   
 0.759
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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