Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mfnDConserved hypothetical protein; Catalyzes the formation of an amide bond between tyramine and the gamma carboxy group of L-glutamate. The enzyme also accepts phenylethylamine in vitro. (308 aa)    
Predicted Functional Partners:
mfnF
Conserved hypothetical protein; Catalyzes the condensation between 5-(aminomethyl)-3- furanmethanol diphosphate (F1-PP) and gamma-glutamyltyramine to produce APMF-Glu.
 
  
 0.992
dys
Deoxyhypusine synthase (dys1); Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
       0.937
mfnA
Group II decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.
 
  
 0.932
mfnE
Delta 1-pyrroline-5-carboxylate synthetase; Catalyzes the formation of 5-(aminomethyl)-3-furanmethanol diphosphate (F1-PP) from 5-(aminomethyl)-3-furanmethanol phosphate (F1- P) and ATP. In vitro, can also act as an adenylate kinase that catalyzes the transfer of a phosphoryl group from ATP to AMP, generating two molecules of ADP.
 
   
 0.925
MJ_0816
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0816.
       0.881
mfnB
Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
 
   
 0.781
cbiH
Cobalamin biosynthesis precorrin-3 methylase (cbiH); Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity).
       0.757
fwdA
Formylmethanofuran dehydrogenase, subunit A (tungsten) (fwdA); Similar to PID:871462 GB:AE000666 PID:1890210 percent identity: 68.95; identified by sequence similarity; putative; Belongs to the metallo-dependent hydrolases superfamily. FwdA/FmdA family.
 
   
 0.754
MJ_0811
Conserved hypothetical protein; Similar to GB:L10328 SP:P03818 PID:290594 PID:2367274 percent identity: 35.29; identified by sequence similarity; putative.
       0.738
MJ_0812
Conserved hypothetical protein; Similar to GB:L10328 SP:P31473 PID:290596 GB:U00096 PID:2367275 percent identity: 34.94; identified by sequence similarity; putative.
       0.737
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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