Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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mptBCmp-binding-factor 1 isolog; Cyclic phosphodiesterase that hydrolyzes the cyclic phosphate of 7,8-dihydroneopterin 2',3'-cyclic phosphate (H2N-cP) and converts it to a mixture of 7,8-dihydroneopterin 2'-phosphate (H2N-2'P) and 7,8- dihydroneopterin 3'-phosphate (H2N-3'P). Is also able to utilize other phosphodiesters as substrates in vitro: hydrolysis of bis-pNPP and pNPPC produces nitrophenyl phosphate, and that of 2',3'-cAMP produces 3'-AMP. ATP, 3',5'-cAMP, GTP, 3',5'-cGMP, and 4',5'-cFMN cannot serve as substrates. (249 aa)    
Predicted Functional Partners:
mptA
Conserved hypothetical protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. It is also able to utilize a variety of GTP analogs as substrates, including GDP, beta,gamma-methylene-GTP and GTP-[gamma- thio]; Belongs to the GTP cyclohydrolase IV family.
  
  
 0.925
MJ_0836
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0836.
       0.631
MJ_0835.2
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 27.83; identified by sequence similarity; putative.
     
 0.582
MJ_0835.1
Hypothetical protein; Brute Force ORF; identified by GeneMark; putative; M. jannaschii predicted coding region MJ0835.1.
       0.567
MJ_0835
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0835.
       0.461
MJ_0833
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0833.
       0.428
MJ_0457
Succinyl-diaminopimelate desuccinylase (dapE); Similar to GB:L42023 SP:P44514 PID:1003108 PID:1222014 PID:1204361 percent identity: 27.75; identified by sequence similarity; putative.
 
     0.420
purL
Phosphoribosylformylglycinamidine synthase II (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...]
  
    0.418
MJ_0832.1
Hypothetical protein; Brute Force ORF; identified by GeneMark; putative; M. jannaschii predicted coding region MJ0832.1.
       0.415
MJ_0834
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0834.
       0.414
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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