STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mfnFConserved hypothetical protein; Catalyzes the condensation between 5-(aminomethyl)-3- furanmethanol diphosphate (F1-PP) and gamma-glutamyltyramine to produce APMF-Glu. (330 aa)    
Predicted Functional Partners:
mfnE
Delta 1-pyrroline-5-carboxylate synthetase; Catalyzes the formation of 5-(aminomethyl)-3-furanmethanol diphosphate (F1-PP) from 5-(aminomethyl)-3-furanmethanol phosphate (F1- P) and ATP. In vitro, can also act as an adenylate kinase that catalyzes the transfer of a phosphoryl group from ATP to AMP, generating two molecules of ADP.
 
  
 0.997
mfnD
Conserved hypothetical protein; Catalyzes the formation of an amide bond between tyramine and the gamma carboxy group of L-glutamate. The enzyme also accepts phenylethylamine in vitro.
 
  
 0.996
mfnB
Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
 
   
 0.936
MJ_0107
Dihydropteroate synthase; Unknown. Does not possess dihydropteroate synthase (DHPS) activity since it does not catalyze the condensation of 6- hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) and 4- aminobenzoate to form 7,8-dihydropteroate.
 
   
 0.906
mfnA
Group II decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.
     
 0.838
mfnC
Aspartate aminotransferase (aspB2); Catalyzes the transamination reaction between 4- (hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) and alanine to produce pyruvate and 5-(aminomethyl)-3-furanmethanol phosphate (F1- P), the precursor for the furan moiety in methanofuran. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
      
 0.766
fwdA
Formylmethanofuran dehydrogenase, subunit A (tungsten) (fwdA); Similar to PID:871462 GB:AE000666 PID:1890210 percent identity: 68.95; identified by sequence similarity; putative; Belongs to the metallo-dependent hydrolases superfamily. FwdA/FmdA family.
 
   
 0.759
ftr
Formylmethanofuran:tetrahydromethanopterin formyltransferase (ftr); Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family.
 
     0.736
mch
N5,N10-methenyl-tetrahydromethanopterin cyclohydrolase (mch); Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family.
 
     0.735
MJ_0227
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 40.07; identified by sequence similarity; putative.
 
   
 0.731
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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