STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
coaBCPantothenate metabolism flavoprotein (dfp); Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa)    
Predicted Functional Partners:
MJ_0209
Conserved hypothetical protein; Catalyzes the condensation of (R)-4-phosphopantoate and beta- alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. Belongs to the archaeal phosphopantothenate synthetase family.
 
  
 0.994
MJ_0969
Conserved hypothetical protein; Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.
 
   
 0.946
coaD
Conserved hypothetical protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family.
    
 0.914
MJ_0001
Aspartate aminotransferase (aspB1); Similar to PID:1146246 SP:P53001 GB:AL009126 percent identity: 44.38; identified by sequence similarity; putative; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
 
  0.886
MJ_1025
Conserved hypothetical protein; Catalyzes the cleavage of L-cysteine to form 2-aminoprop-2- enoate and sulfide. The former then spontaneously hydrolyzes to pyruvate and NH(3). May be responsible for the production of sulfide required for the biosynthesis of iron-sulfur centers in this archaea. Is very specific for L-cysteine, with no activity being detected with D-cysteine, L-homocysteine, 3-mercaptopropionate (cysteine without the amino group), cysteamine (cysteine without the carboxylate), or mercaptolactate (the hydroxyl analog of cysteine).
    
  0.803
nadX
Conserved hypothetical protein; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
       0.791
vapC1
Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB1 (By similarity). Belongs to the PINc/VapC protein family.
       0.782
MJ_0104
DNA-binding protein, probably DNA helicase; Similar to GB:M64979 GB:L14754 GB:L24544 SP:P38935 PID:401776 percent identity: 34.98; identified by sequence similarity; putative; Belongs to the DNA2/NAM7 helicase family.
   
 
 0.772
MJ_0912
Conserved hypothetical protein; Similar to GP:1788638 percent identity: 31.17; identified by sequence similarity; putative.
   
 
 0.772
ilvC
Ketol-acid reductoisomerase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
      
 0.714
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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