node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MJ_0942 | fen | MJ_0942 | MJ_1444 | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.964 |
MJ_0942 | mre11 | MJ_0942 | MJ_1323 | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | DNA repair protein RAD32 (rad32); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. | 0.938 |
MJ_0942 | rpoD | MJ_0942 | MJ_0192 | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | DNA-directed RNA polymerase, subunit D (rpoD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.979 |
MJ_0942 | rpoH | MJ_0942 | MJ_1039 | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | DNA-directed RNA polymerase, subunit H (rpoH); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.978 |
MJ_0942 | rpoK | MJ_0942 | MJ_0197 | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | DNA-directed RNA polymerase, subunit K (rpoK); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. | 0.976 |
MJ_0942 | rpoN | MJ_0942 | MJ_0196 | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | DNA-directed RNA polymerase, subunit N (rpoN); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. | 0.975 |
MJ_0942 | tbp | MJ_0942 | MJ_0507 | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | Transcription initiation factor IID, TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | 0.973 |
MJ_0942 | tfb | MJ_0942 | MJ_0782 | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). | 0.977 |
MJ_0942 | tfe | MJ_0942 | MJ_0777 | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | Putative transcription initiation factor (TFIIE, subunit alpha); Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and d [...] | 0.986 |
MJ_0942 | tfs | MJ_0942 | MJ_1148 | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | Transcription-associated protein ('TFIIS'); Induces RNA cleavage activity in the RNA polymerase. In its presence, the cleavage activity of the RNA polymerase truncates the RNA back to position +15 in a stepwise manner by releasing mainly dinucleotides from the 3'-end of the nascent RNA. The truncated RNAs are able to continue elongation. Involved in transcriptional proofreading and fidelity. Misincorporation of nucleotides during elongation of transcription leads to arrested elongation complexes which are rescued by TFS-promoted removal of a dinucleotide from the 3'-end. TFS is able to [...] | 0.970 |
fen | MJ_0942 | MJ_1444 | MJ_0942 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | 0.964 |
fen | mre11 | MJ_1444 | MJ_1323 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | DNA repair protein RAD32 (rad32); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. | 0.985 |
fen | rpoD | MJ_1444 | MJ_0192 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | DNA-directed RNA polymerase, subunit D (rpoD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.665 |
fen | tbp | MJ_1444 | MJ_0507 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | Transcription initiation factor IID, TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | 0.703 |
fen | tfs | MJ_1444 | MJ_1148 | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | Transcription-associated protein ('TFIIS'); Induces RNA cleavage activity in the RNA polymerase. In its presence, the cleavage activity of the RNA polymerase truncates the RNA back to position +15 in a stepwise manner by releasing mainly dinucleotides from the 3'-end of the nascent RNA. The truncated RNAs are able to continue elongation. Involved in transcriptional proofreading and fidelity. Misincorporation of nucleotides during elongation of transcription leads to arrested elongation complexes which are rescued by TFS-promoted removal of a dinucleotide from the 3'-end. TFS is able to [...] | 0.837 |
mre11 | MJ_0942 | MJ_1323 | MJ_0942 | DNA repair protein RAD32 (rad32); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | 0.938 |
mre11 | fen | MJ_1323 | MJ_1444 | DNA repair protein RAD32 (rad32); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.985 |
mre11 | rpoH | MJ_1323 | MJ_1039 | DNA repair protein RAD32 (rad32); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. | DNA-directed RNA polymerase, subunit H (rpoH); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.494 |
rpoD | MJ_0942 | MJ_0192 | MJ_0942 | DNA-directed RNA polymerase, subunit D (rpoD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative. | 0.979 |
rpoD | fen | MJ_0192 | MJ_1444 | DNA-directed RNA polymerase, subunit D (rpoD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA repair protein RAD2 (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] | 0.665 |