STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_09733-phosphoadenosine 5-phosphosulfate sulfotransferase (cysH); Similar to GB:M23008 SP:P17854 GB:Y07525 PID:145682 PID:41198 percent identity: 28.57; identified by sequence similarity; putative; In the C-terminal section; belongs to the PAPS reductase family. (411 aa)    
Predicted Functional Partners:
MJ_1241
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1241.
  
 
 0.952
MJ_0066
Sulfate adenylate transferase, subunit 2 (cysD); Similar to SP:Q10599 PID:1322409 percent identity: 28.80; identified by sequence similarity; putative; In the C-terminal section; belongs to the PAPS reductase family.
  
  
 
0.911
cobA
uroporphyrin-III C-methyltransferase (cobA); Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin.
 
  
 0.805
wtpB
Sulfate transport system permease protein (cysT); Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
  
  
 0.779
vapC2
Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB2 (By similarity). Belongs to the PINc/VapC protein family.
       0.773
vapB2
Hypothetical protein; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC2 (Potential).
       0.773
hcp
[6Fe-6S] prismane-containing protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
  
  
 0.677
recJ
Conserved hypothetical protein; Single-stranded-DNA-specific exonuclease.
     
 0.618
MJ_0976
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0976.
       0.545
cbiX
Conserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin.
  
  
 0.540
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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