STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_0993Hydrogenase expression/formation protein (hypD); Similar to SP:P31903 GB:X70183 PID:38775 percent identity: 42.46; identified by sequence similarity; putative; Belongs to the HypD family. (358 aa)    
Predicted Functional Partners:
MJ_0676
Hydrogenase expression/formation protein (hypE); Similar to GB:X52974 SP:P40599 PID:48737 PID:536795 percent identity: 44.88; identified by sequence similarity; putative; Belongs to the HypE family.
 
 0.997
MJ_0200
Hydrogenase expression/formation protein (hypC); Similar to GB:L23970 SP:P31881 GB:X63650 PID:39244 PID:398010 percent identity: 40.00; identified by sequence similarity; putative; Belongs to the HupF/HypC family.
 
 
 0.993
hypF
Hydrogenase expression regulatory protein (hypF); Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
  
 0.938
hypB
Hydrogenase expression/formation protein (hypB); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion; Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.
  
  
 0.861
hypA
Hydrogenase expression/formation protein (hypA); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.858
hemD
Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
     
 0.812
MJ_0995
VAR1 protein isolog; Similar to GP:343962 percent identity: 26.19; identified by sequence similarity; putative.
       0.793
MJ_0120
Urease accessory protein (ureG); Similar to GB:L24101 SP:P42871 PID:431755 percent identity: 34.53; identified by sequence similarity; putative.
  
  
 0.768
vhuA
Methylviologen-reducing hydrogenase, alpha chain (vhuA); Similar to GB:X61204 PID:44799 PID:1747408 percent identity: 77.03; identified by sequence similarity; putative.
 
 
 0.604
MJ_0996
Conserved hypothetical protein; Probable metalloprotease.
       0.572
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.