STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thsThermosome subunit; Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity (542 aa)    
Predicted Functional Partners:
glmS
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
 
 
 0.990
MJ0285
Small heat shock protein HSP16.5; Chaperone that confers thermal protection to other proteins; Belongs to the small heat shock protein (HSP20) family
  
  
 0.928
vapC6
Ribonuclease VapC6; Toxic component of a type II toxin-antitoxin (TA) system. An RNase
     
 0.816
tbp
TATA-box-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity)
 
 
 
 0.800
eif5a
Translation initiation factor 5A; Functions by promoting the formation of the first peptide bond
 
 
 0.798
MJ0443
KH domain-containing protein MJ0443; Similar to GB:X59720 SP:P25586 PID:5300 percent identity: 27.78; identified by sequence similarity; putative
 
  
 0.792
tfe
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]
 
   
 0.782
pgk
Phosphoglycerate kinase; Similar to GB:M55529 SP:P20971 PID:149808 percent identity: 56.76; identified by sequence similarity; putative; Belongs to the phosphoglycerate kinase family
  
 
 0.779
infB
Probable translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity)
 
 
 0.778
rpoA1
DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
 
 
 0.775
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii DSM2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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