node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MJ_1004 | MJ_1005 | MJ_1004 | MJ_1005 | Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 48.11; identified by sequence similarity; putative. | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1005. | 0.968 |
MJ_1004 | dacZ | MJ_1004 | MJ_1002 | Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 48.11; identified by sequence similarity; putative. | Conserved hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation (By similarity). | 0.453 |
MJ_1004 | hacA | MJ_1004 | MJ_1003 | Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 48.11; identified by sequence similarity; putative. | 3-isopropylmalate dehydratase (leuC); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate, and even the non-physiological cis-homo(4)-aconitate with similar efficiency. These reactions are pa [...] | 0.851 |
MJ_1005 | MJ_1004 | MJ_1005 | MJ_1004 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1005. | Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 48.11; identified by sequence similarity; putative. | 0.968 |
MJ_1005 | dacZ | MJ_1005 | MJ_1002 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1005. | Conserved hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation (By similarity). | 0.453 |
MJ_1005 | hacA | MJ_1005 | MJ_1003 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1005. | 3-isopropylmalate dehydratase (leuC); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate, and even the non-physiological cis-homo(4)-aconitate with similar efficiency. These reactions are pa [...] | 0.851 |
aksA | aksF | MJ_0503 | MJ_1596 | 2-isopropylmalate synthase (leuA); Catalyzes the condensation of alpha-ketoglutarate and acetyl- CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)- homo(3)citrate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase 2 (leuB2); Catalyzes the NAD-dependent oxidation and decarboxylation of (2R,3S)-homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate), (2R,3S)-homo(2)-isocitrate and (2R,3S)-homo(3)-isocitrate, into 2- oxoadipate, 2-oxopimelate, and 2-oxosuberate, respectively. This last compound is a precursor to coenzyme B and biotin in methanoarchaea. Is also able to produce 2-oxoazelate from (2R,3S)-homo(4)-isocitrate. Is not able to use NADP as an oxidant. | 0.992 |
aksA | hacA | MJ_0503 | MJ_1003 | 2-isopropylmalate synthase (leuA); Catalyzes the condensation of alpha-ketoglutarate and acetyl- CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)- homo(3)citrate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase (leuC); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate, and even the non-physiological cis-homo(4)-aconitate with similar efficiency. These reactions are pa [...] | 0.977 |
aksA | hacB | MJ_0503 | MJ_1271 | 2-isopropylmalate synthase (leuA); Catalyzes the condensation of alpha-ketoglutarate and acetyl- CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)- homo(3)citrate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase (leuD); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate, and even the non-physiological cis-homo(4)-aconitate with similar efficiency. These reactions are pa [...] | 0.974 |
aksA | ilvC | MJ_0503 | MJ_1543 | 2-isopropylmalate synthase (leuA); Catalyzes the condensation of alpha-ketoglutarate and acetyl- CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)- homo(3)citrate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.792 |
aksA | ilvD | MJ_0503 | MJ_1276 | 2-isopropylmalate synthase (leuA); Catalyzes the condensation of alpha-ketoglutarate and acetyl- CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)- homo(3)citrate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase (ilvD); Similar to GB:M90761 SP:Q02139 PID:149431 percent identity: 44.53; identified by sequence similarity; putative; Belongs to the IlvD/Edd family. | 0.761 |
aksA | leuB | MJ_0503 | MJ_0720 | 2-isopropylmalate synthase (leuA); Catalyzes the condensation of alpha-ketoglutarate and acetyl- CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)- homo(3)citrate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase 1 (leuB1); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate, which decarboxylates to 4-methyl-2-oxopentanoate (2- oxoisocaproate). Also catalyzes the oxidative decarboxylation of 3- methylmalate to 2-oxobutyrate, and that of D-malate to pyruvate. Cannot use NADP(+) instead of NAD(+). Cannot catalyze the oxidation of L- malate, L-tartrate, D-tartrate, DL-isocitrate, or DL-lactate. | 0.790 |
aksA | leuD | MJ_0503 | MJ_1277 | 2-isopropylmalate synthase (leuA); Catalyzes the condensation of alpha-ketoglutarate and acetyl- CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)- homo(3)citrate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase (leuD); Enzyme with broad specificity that catalyzes reversible hydroxyacid isomerizations via dehydration/hydration reactions. Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate, a step involved in leucine biosynthesis. Catalyzes the isomerization between 2-methylmalate and 3-methylmalate, via the formation of 2-methylmaleate (citraconate), a step involved in isoleucine biosynthesis. Also displays malease activity, i.e. catalyzes the hydration of maleate to form (R)-malate. | 0.739 |
aksF | aksA | MJ_1596 | MJ_0503 | 3-isopropylmalate dehydrogenase 2 (leuB2); Catalyzes the NAD-dependent oxidation and decarboxylation of (2R,3S)-homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate), (2R,3S)-homo(2)-isocitrate and (2R,3S)-homo(3)-isocitrate, into 2- oxoadipate, 2-oxopimelate, and 2-oxosuberate, respectively. This last compound is a precursor to coenzyme B and biotin in methanoarchaea. Is also able to produce 2-oxoazelate from (2R,3S)-homo(4)-isocitrate. Is not able to use NADP as an oxidant. | 2-isopropylmalate synthase (leuA); Catalyzes the condensation of alpha-ketoglutarate and acetyl- CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)- homo(3)citrate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.992 |
aksF | hacA | MJ_1596 | MJ_1003 | 3-isopropylmalate dehydrogenase 2 (leuB2); Catalyzes the NAD-dependent oxidation and decarboxylation of (2R,3S)-homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate), (2R,3S)-homo(2)-isocitrate and (2R,3S)-homo(3)-isocitrate, into 2- oxoadipate, 2-oxopimelate, and 2-oxosuberate, respectively. This last compound is a precursor to coenzyme B and biotin in methanoarchaea. Is also able to produce 2-oxoazelate from (2R,3S)-homo(4)-isocitrate. Is not able to use NADP as an oxidant. | 3-isopropylmalate dehydratase (leuC); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate, and even the non-physiological cis-homo(4)-aconitate with similar efficiency. These reactions are pa [...] | 0.998 |
aksF | hacB | MJ_1596 | MJ_1271 | 3-isopropylmalate dehydrogenase 2 (leuB2); Catalyzes the NAD-dependent oxidation and decarboxylation of (2R,3S)-homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate), (2R,3S)-homo(2)-isocitrate and (2R,3S)-homo(3)-isocitrate, into 2- oxoadipate, 2-oxopimelate, and 2-oxosuberate, respectively. This last compound is a precursor to coenzyme B and biotin in methanoarchaea. Is also able to produce 2-oxoazelate from (2R,3S)-homo(4)-isocitrate. Is not able to use NADP as an oxidant. | 3-isopropylmalate dehydratase (leuD); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate, and even the non-physiological cis-homo(4)-aconitate with similar efficiency. These reactions are pa [...] | 0.996 |
aksF | ilvC | MJ_1596 | MJ_1543 | 3-isopropylmalate dehydrogenase 2 (leuB2); Catalyzes the NAD-dependent oxidation and decarboxylation of (2R,3S)-homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate), (2R,3S)-homo(2)-isocitrate and (2R,3S)-homo(3)-isocitrate, into 2- oxoadipate, 2-oxopimelate, and 2-oxosuberate, respectively. This last compound is a precursor to coenzyme B and biotin in methanoarchaea. Is also able to produce 2-oxoazelate from (2R,3S)-homo(4)-isocitrate. Is not able to use NADP as an oxidant. | Ketol-acid reductoisomerase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.838 |
aksF | ilvD | MJ_1596 | MJ_1276 | 3-isopropylmalate dehydrogenase 2 (leuB2); Catalyzes the NAD-dependent oxidation and decarboxylation of (2R,3S)-homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate), (2R,3S)-homo(2)-isocitrate and (2R,3S)-homo(3)-isocitrate, into 2- oxoadipate, 2-oxopimelate, and 2-oxosuberate, respectively. This last compound is a precursor to coenzyme B and biotin in methanoarchaea. Is also able to produce 2-oxoazelate from (2R,3S)-homo(4)-isocitrate. Is not able to use NADP as an oxidant. | Dihydroxy-acid dehydratase (ilvD); Similar to GB:M90761 SP:Q02139 PID:149431 percent identity: 44.53; identified by sequence similarity; putative; Belongs to the IlvD/Edd family. | 0.818 |
aksF | leuD | MJ_1596 | MJ_1277 | 3-isopropylmalate dehydrogenase 2 (leuB2); Catalyzes the NAD-dependent oxidation and decarboxylation of (2R,3S)-homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate), (2R,3S)-homo(2)-isocitrate and (2R,3S)-homo(3)-isocitrate, into 2- oxoadipate, 2-oxopimelate, and 2-oxosuberate, respectively. This last compound is a precursor to coenzyme B and biotin in methanoarchaea. Is also able to produce 2-oxoazelate from (2R,3S)-homo(4)-isocitrate. Is not able to use NADP as an oxidant. | 3-isopropylmalate dehydratase (leuD); Enzyme with broad specificity that catalyzes reversible hydroxyacid isomerizations via dehydration/hydration reactions. Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate, a step involved in leucine biosynthesis. Catalyzes the isomerization between 2-methylmalate and 3-methylmalate, via the formation of 2-methylmaleate (citraconate), a step involved in isoleucine biosynthesis. Also displays malease activity, i.e. catalyzes the hydration of maleate to form (R)-malate. | 0.834 |
dacZ | MJ_1004 | MJ_1002 | MJ_1004 | Conserved hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation (By similarity). | Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 48.11; identified by sequence similarity; putative. | 0.453 |