STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
carACarbamoyl-phosphate synthase, small (or glutamine) subunit (carA); Similar to GB:M59757 SP:P25993 PID:143389 GB:AL009126 percent identity: 48.55; identified by sequence similarity; putative; Belongs to the CarA family. (354 aa)    
Predicted Functional Partners:
carB1
Carbamoyl-phosphate synthase, medium subunit (carB1); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 53.32; identified by sequence similarity; putative; Belongs to the CarB family.
 0.999
carB2
Carbamoyl-phosphate synthase, large subunit (carB2); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 52.95; identified by sequence similarity; putative; Belongs to the CarB family.
 0.999
pyrB
Aspartate carbamoyltransferase catalytic chain (pyrB); Similar to GP:1572497 percent identity: 59.12; identified by sequence similarity; putative.
 
 
 0.999
pyrC
Dihydroorotase (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
  
 0.998
pyrD
Dihydroorotase dehydrogenase (pyrD); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
  
  
 0.985
pyrK
Cytochrome-c3 hydrogenase, gamma chain; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
  
  
 0.980
argF
Ornithine carbamoyltransferase (argF); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
 
   
  0.979
pyrF
Conserved hypothetical protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
  
 0.978
pyrE
Orotate phosphoribosyl transferase (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
  
 0.978
purF
Amidophosphoribosyltransferase (purF); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 
 0.976
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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