STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mtdN5,N10-methylene-tetrahydromethanopterin dehydrogenase (mtd); Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (277 aa)    
Predicted Functional Partners:
hmd
H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenease (hmd); Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
     
 0.976
mch
N5,N10-methenyl-tetrahydromethanopterin cyclohydrolase (mch); Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family.
    
 0.976
mer
N5,N10-methylene-tetrahydromethanopterin reductase (mer); Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family.
   
 
 0.975
MJ_0727
Coenzyme F420-reducing hydrogenase, alpha subunit; Similar to GB:J02914 SP:P19496 PID:551889 GB:AE000666 percent identity: 27.08; identified by sequence similarity; putative.
     
 0.970
fae-hps
D-arabino 3-hexulose 6-phosphate formaldehyde lyase isolog; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
     
 0.949
frhB
Coenzyme F420-reducing hydrogenase, beta subunit (frhB); Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. Belongs to the FrhB family.
   
 
 0.913
MJ_0725
Coenzyme F420-reducing hydrogenase, beta subunit; Similar to GB:J02914 SP:P19499 PID:149718 GB:AE000666 percent identity: 42.24; identified by sequence similarity; putative; Belongs to the FrhB family.
   
 
 0.913
MJ_1349
Coenzyme F420-reducing hydrogenase, beta subunit; Similar to GB:X61201 PID:809731 SP:Q00391 percent identity: 35.74; identified by sequence similarity; putative; Belongs to the FrhB family.
   
 
 0.911
glyA
Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. The use of tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate is 450-fold less efficient than that of H4MPT. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine and L-threo- beta-phenylserine; Belongs to the SHMT family.
     
 0.907
frhD
Coenzyme F420-reducing hydrogenase, delta subunit (frcD); Similar to GB:X61202 PID:44706 percent identity: 65.70; identified by sequence similarity; putative; Belongs to the peptidase A31 family.
     
 0.902
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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