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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_1083Iron-sulfur flavoprotein (isf); Redox-active protein probably involved in electron transport; Belongs to the SsuE family. Isf subfamily. (193 aa)    
Predicted Functional Partners:
MJ_0392
Conserved hypothetical protein; A site-2 regulated intramembrane protease (S2P) that cleaves type-2 transmembrane proteins within their membrane-spanning domains; its endogenous substrate is unknown. Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this enzyme), while cytoplasmic proteases finish degr [...]
  
 
 0.897
MJ_1081
Conserved hypothetical protein; Similar to SP:P32698 PID:396391 GB:U00096 PID:1790491 percent identity: 38.18; identified by sequence similarity; putative; Belongs to the UPF0047 family.
       0.890
aroE
Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
    0.618
MJ_1082
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 34.78; identified by sequence similarity; putative; To M.jannaschii MJ1503.
       0.586
MJ_1086
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 47.46; identified by sequence similarity; putative.
       0.502
MJ_1085
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1085.
       0.501
MJ_0480
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 27.49; identified by sequence similarity; putative.
   
    0.497
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
       0.485
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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