Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (312 aa)    
Predicted Functional Partners:
hmgA
3-hydroxy-3-methylglutaryl coenzyme A reductase; Converts HMG-CoA to mevalonate.
 
 0.991
fni
Carotenoid biosynthetic gene ERWCRTS isolog; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
  
 0.937
MJ_1086
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 47.46; identified by sequence similarity; putative.
       0.922
MJ_1313
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 55.44; identified by sequence similarity; putative; To M.thermoautotrophicum MTH1421.
    
  0.911
MJ_0044
Conserved hypothetical protein; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. Has no activity with farnesyl phosphate; Belongs to the isopentenyl phosphate kinase family.
 
   
 0.904
MJ_1407
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 48.00; identified by sequence similarity; putative; Belongs to the UPF0107 family.
    
  0.902
idsA
Bifunctional short chain isoprenyl diphosphate synthase (idsA); Similar to PID:913252 SP:Q53479 percent identity: 48.47; identified by sequence similarity; putative.
 
  
 0.878
MJ_1546
Putative beta-ketoacyl acyl-carrier-protein synthase (fabH); Similar to PID:1197357 percent identity: 64.20; identified by sequence similarity; putative; Belongs to the thiolase-like superfamily. UPF0219 family.
 
  
 0.856
sepS
phenylalanyl-tRNA synthase alpha subunit; Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
 
 
 0.817
selB
Putative translation factor, EF-1 alpha family; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.
  
  
 0.812
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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