Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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nifBnifB protein (nifB); Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster. (300 aa)    
Predicted Functional Partners:
nifH
Nitrogenase iron protein (nifH); The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
 
  
 0.905
MJ_0640
Conserved hypothetical protein; Similar to GP:1001832 percent identity: 33.81; identified by sequence similarity; putative.
       0.685
queE
Coenzyme PQQ synthesis protein III isolog (Haemophilus influenzae}; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
     
 0.683
MJ_0805
Conserved hypothetical protein; Similar to PID:1419841 percent identity: 27.98; identified by sequence similarity; putative.
       0.648
MJ_0800
(R)-2-hydroxyglutaryl-CoA dehydratase activator; Similar to SP:P11568 GB:X59645 PID:433932 percent identity: 31.78; identified by sequence similarity; putative.
       0.627
queC
ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
     
 0.623
MJ_0404
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 65.03; identified by sequence similarity; putative.
       0.609
MJ_1092
Urease accesory protein (ureH); Efflux system for nickel and cobalt; Belongs to the NiCoT transporter (TC 2.A.52) family.
       0.505
MJ_0802
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 32.96; identified by sequence similarity; putative.
       0.423
queD
Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.
       0.423
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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