STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
thrBHomoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (300 aa)    
Predicted Functional Partners:
thrC
Threonine synthase (thrC); Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
 
 0.997
hom
Homoserine dehydrogenase (hom); Similar to SP:P19582 GB:M23217 PID:558494 PID:809663 GB:AL009126 percent identity: 40.32; identified by sequence similarity; putative; Belongs to the homoserine dehydrogenase family.
 
 0.997
MJ_0571
Aspartate kinase (lysC); Similar to PID:928811 SP:P53553 percent identity: 40.95; identified by sequence similarity; putative; Belongs to the aspartokinase family.
 
 
 0.972
trkA
TRK system potassium uptake protein (trkA); Part of a potassium transport system.
  
    0.944
purM
Phosphoribosylformylglycinamidine cyclo-ligase (purM); Similar to GB:J02732 SP:P12043 PID:143371 GB:AL009126 percent identity: 39.76; identified by sequence similarity; putative.
    
 0.912
ilvE
Branched-chain amino acid aminotransferase (ilvE); Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.890
asd
Aspartate-semialdehyde dehydrogenase (asd); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate. To a lesser extent, is able to use NAD instead of NADP. Belongs to the aspartate-semialdehyde dehydrogenase family.
  
  
 0.880
metE
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase (metE); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate (By similarity).
 
 
 0.878
MJ_1106
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 56.49; identified by sequence similarity; putative; To M.thermoautotrophicum MTH236.
  
    0.834
ilvD
Dihydroxy-acid dehydratase (ilvD); Similar to GB:M90761 SP:Q02139 PID:149431 percent identity: 44.53; identified by sequence similarity; putative; Belongs to the IlvD/Edd family.
 
  
 0.726
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.