node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MJ_0457 | dapB | MJ_0457 | MJ_0422 | Succinyl-diaminopimelate desuccinylase (dapE); Similar to GB:L42023 SP:P44514 PID:1003108 PID:1222014 PID:1204361 percent identity: 27.75; identified by sequence similarity; putative. | Dihydrodipicolinate reductase (dapB); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | 0.421 |
MJ_0457 | dapF | MJ_0457 | MJ_1119 | Succinyl-diaminopimelate desuccinylase (dapE); Similar to GB:L42023 SP:P44514 PID:1003108 PID:1222014 PID:1204361 percent identity: 27.75; identified by sequence similarity; putative. | Diaminopimelate epimerase (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. | 0.927 |
MJ_0457 | dapL | MJ_0457 | MJ_1391 | Succinyl-diaminopimelate desuccinylase (dapE); Similar to GB:L42023 SP:P44514 PID:1003108 PID:1222014 PID:1204361 percent identity: 27.75; identified by sequence similarity; putative. | Putative aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate, a reaction that requires three enzymes in E.coli. | 0.915 |
MJ_1118 | MJ_1120 | MJ_1118 | MJ_1120 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 32.88; identified by sequence similarity; putative. | Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 30.16; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family. | 0.842 |
MJ_1118 | cobY | MJ_1118 | MJ_1117 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 32.88; identified by sequence similarity; putative. | Conserved hypothetical protein; Guanylyltransferase that catalyzes the synthesis of adenosylcobinamide-GDP (AdoCbi-GDP) from adenosylcobinamide-phosphate (AdoCbi-P) and GTP. Is involved in adenosylcobalamin biosynthesis. Binds one GTP per dimer. Cannot use other NTPs or GDP. Does not display AdoCbi kinase activity. Is also able to catalyze the condensation of 2- phospho-L-lactate (LP) with GTP in vitro to form PPi and (2S)-lactyl-2- diphospho-5'-guanosine (LPPG), but is much less efficient than CofC, the presumed enzyme catalyzing this reaction in vivo. | 0.964 |
MJ_1118 | dapF | MJ_1118 | MJ_1119 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 32.88; identified by sequence similarity; putative. | Diaminopimelate epimerase (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. | 0.887 |
MJ_1120 | MJ_1118 | MJ_1120 | MJ_1118 | Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 30.16; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family. | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 32.88; identified by sequence similarity; putative. | 0.842 |
MJ_1120 | cobY | MJ_1120 | MJ_1117 | Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 30.16; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family. | Conserved hypothetical protein; Guanylyltransferase that catalyzes the synthesis of adenosylcobinamide-GDP (AdoCbi-GDP) from adenosylcobinamide-phosphate (AdoCbi-P) and GTP. Is involved in adenosylcobalamin biosynthesis. Binds one GTP per dimer. Cannot use other NTPs or GDP. Does not display AdoCbi kinase activity. Is also able to catalyze the condensation of 2- phospho-L-lactate (LP) with GTP in vitro to form PPi and (2S)-lactyl-2- diphospho-5'-guanosine (LPPG), but is much less efficient than CofC, the presumed enzyme catalyzing this reaction in vivo. | 0.827 |
MJ_1120 | dapF | MJ_1120 | MJ_1119 | Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 30.16; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family. | Diaminopimelate epimerase (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. | 0.931 |
asd | carB1 | MJ_0205 | MJ_1378 | Aspartate-semialdehyde dehydrogenase (asd); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate. To a lesser extent, is able to use NAD instead of NADP. Belongs to the aspartate-semialdehyde dehydrogenase family. | Carbamoyl-phosphate synthase, medium subunit (carB1); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 53.32; identified by sequence similarity; putative; Belongs to the CarB family. | 0.411 |
asd | carB2 | MJ_0205 | MJ_1381 | Aspartate-semialdehyde dehydrogenase (asd); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate. To a lesser extent, is able to use NAD instead of NADP. Belongs to the aspartate-semialdehyde dehydrogenase family. | Carbamoyl-phosphate synthase, large subunit (carB2); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 52.95; identified by sequence similarity; putative; Belongs to the CarB family. | 0.411 |
asd | dapB | MJ_0205 | MJ_0422 | Aspartate-semialdehyde dehydrogenase (asd); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate. To a lesser extent, is able to use NAD instead of NADP. Belongs to the aspartate-semialdehyde dehydrogenase family. | Dihydrodipicolinate reductase (dapB); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | 0.862 |
asd | dapF | MJ_0205 | MJ_1119 | Aspartate-semialdehyde dehydrogenase (asd); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate. To a lesser extent, is able to use NAD instead of NADP. Belongs to the aspartate-semialdehyde dehydrogenase family. | Diaminopimelate epimerase (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. | 0.917 |
asd | lysA | MJ_0205 | MJ_1097 | Aspartate-semialdehyde dehydrogenase (asd); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate. To a lesser extent, is able to use NAD instead of NADP. Belongs to the aspartate-semialdehyde dehydrogenase family. | Diaminopimelate decarboxylase (lysA); Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.769 |
carB1 | asd | MJ_1378 | MJ_0205 | Carbamoyl-phosphate synthase, medium subunit (carB1); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 53.32; identified by sequence similarity; putative; Belongs to the CarB family. | Aspartate-semialdehyde dehydrogenase (asd); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate. To a lesser extent, is able to use NAD instead of NADP. Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.411 |
carB1 | carB2 | MJ_1378 | MJ_1381 | Carbamoyl-phosphate synthase, medium subunit (carB1); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 53.32; identified by sequence similarity; putative; Belongs to the CarB family. | Carbamoyl-phosphate synthase, large subunit (carB2); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 52.95; identified by sequence similarity; putative; Belongs to the CarB family. | 0.987 |
carB1 | dapB | MJ_1378 | MJ_0422 | Carbamoyl-phosphate synthase, medium subunit (carB1); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 53.32; identified by sequence similarity; putative; Belongs to the CarB family. | Dihydrodipicolinate reductase (dapB); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | 0.546 |
carB1 | dapF | MJ_1378 | MJ_1119 | Carbamoyl-phosphate synthase, medium subunit (carB1); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 53.32; identified by sequence similarity; putative; Belongs to the CarB family. | Diaminopimelate epimerase (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. | 0.916 |
carB2 | asd | MJ_1381 | MJ_0205 | Carbamoyl-phosphate synthase, large subunit (carB2); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 52.95; identified by sequence similarity; putative; Belongs to the CarB family. | Aspartate-semialdehyde dehydrogenase (asd); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate. To a lesser extent, is able to use NAD instead of NADP. Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.411 |
carB2 | carB1 | MJ_1381 | MJ_1378 | Carbamoyl-phosphate synthase, large subunit (carB2); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 52.95; identified by sequence similarity; putative; Belongs to the CarB family. | Carbamoyl-phosphate synthase, medium subunit (carB1); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 53.32; identified by sequence similarity; putative; Belongs to the CarB family. | 0.987 |