STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dapFDiaminopimelate epimerase (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (295 aa)    
Predicted Functional Partners:
lysA
Diaminopimelate decarboxylase (lysA); Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
 
 0.994
dapL
Putative aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate, a reaction that requires three enzymes in E.coli.
  
 0.989
dapB
Dihydrodipicolinate reductase (dapB); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
 
   
 0.936
MJ_1120
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 30.16; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
     
 0.933
dapA
Dihydrodipicolinate synthase (dapA); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
  
 0.927
MJ_0457
Succinyl-diaminopimelate desuccinylase (dapE); Similar to GB:L42023 SP:P44514 PID:1003108 PID:1222014 PID:1204361 percent identity: 27.75; identified by sequence similarity; putative.
    
 0.924
carB1
Carbamoyl-phosphate synthase, medium subunit (carB1); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 53.32; identified by sequence similarity; putative; Belongs to the CarB family.
    
 0.913
carB2
Carbamoyl-phosphate synthase, large subunit (carB2); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 52.95; identified by sequence similarity; putative; Belongs to the CarB family.
    
 0.913
MJ_1118
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 32.88; identified by sequence similarity; putative.
       0.869
cobY
Conserved hypothetical protein; Guanylyltransferase that catalyzes the synthesis of adenosylcobinamide-GDP (AdoCbi-GDP) from adenosylcobinamide-phosphate (AdoCbi-P) and GTP. Is involved in adenosylcobalamin biosynthesis. Binds one GTP per dimer. Cannot use other NTPs or GDP. Does not display AdoCbi kinase activity. Is also able to catalyze the condensation of 2- phospho-L-lactate (LP) with GTP in vitro to form PPi and (2S)-lactyl-2- diphospho-5'-guanosine (LPPG), but is much less efficient than CofC, the presumed enzyme catalyzing this reaction in vivo.
       0.843
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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