STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_1120Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 30.16; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family. (279 aa)    
Predicted Functional Partners:
dapF
Diaminopimelate epimerase (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine.
  
  
 0.931
MJ_1118
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 32.88; identified by sequence similarity; putative.
       0.842
cobY
Conserved hypothetical protein; Guanylyltransferase that catalyzes the synthesis of adenosylcobinamide-GDP (AdoCbi-GDP) from adenosylcobinamide-phosphate (AdoCbi-P) and GTP. Is involved in adenosylcobalamin biosynthesis. Binds one GTP per dimer. Cannot use other NTPs or GDP. Does not display AdoCbi kinase activity. Is also able to catalyze the condensation of 2- phospho-L-lactate (LP) with GTP in vitro to form PPi and (2S)-lactyl-2- diphospho-5'-guanosine (LPPG), but is much less efficient than CofC, the presumed enzyme catalyzing this reaction in vivo.
       0.827
MJ_1123
Conserved hypothetical protein; Similar to SP:Q10853 PID:1403450 percent identity: 34.00; identified by sequence similarity; putative; To M.jannaschii MJ0638 and MJ1252 and M.tuberculosis Rv2003c.
       0.798
hel308
Putative SKI2-family helicase; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks; Belongs to the helicase family. Hel308 subfamily.
       0.715
aglB
Putative transmembrane oligosaccharyl transferase; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (ManNAcGlc-2,3-diNAcAGlcNAc in Methanococci) from the lipid carrier dolichol-monophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Involved in the assembly of an N-linked disaccharide that decorates the S-layer glycoprotein and flagellins.
 
     0.617
MJ_0138
Cobyric acid synthase (cbiP); Similar to GB:M62866 SP:P29932 PID:151151 percent identity: 33.62; identified by sequence similarity; putative.
 
    0.606
MJ_0774
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0774.
 
  
 0.605
MJ_0296
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0296.
  
  
 0.555
cfbE
Conserved hypothetical protein; Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the activation the g-propionate side chain of 15,17(3)-seco-F430-17(3)-acid (seco-F430) for intramolecular C-C bond formation to yield the carbocyclic F ring of coenzyme F430. Belongs to the MurCDEF family.
 
  
 0.525
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.