STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
comBConserved hypothetical protein; Hydrolyzes both enantiomers of 2-phosphosulfolactate. Able to hydrolyze both enantiomers of 2-hydroxycarboxylic acids with pseudosymmetric centers of inversion. Specifically hydrolyzes (S)- phospholactate and (S)-phosphoglycerate. (257 aa)    
Predicted Functional Partners:
comA
Conserved hypothetical protein; Catalyzes the addition of sulfite to phosphoenolpyruvate (PEP) to yield (2R)-phospho-3-sulfolactate (PSL).
 
 
 0.998
comC
Malate dehydrogenase; Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthesis of both coenzyme M (with (R)-sulfolactate) and methanopterin (with alpha- ketoglutarate).
     
 0.992
rnp3
Hypothetical protein; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
       0.946
MJ_1157
Conserved hypothetical protein; Similar to GP:1655726 percent identity: 32.52; identified by sequence similarity; putative; Belongs to the TtcA family.
   
 
 0.882
MJ_0206
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 50.38; identified by sequence similarity; putative.
   
    0.843
MJ_1141
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 38.92; identified by sequence similarity; putative.
       0.626
MJ_1142
Arsenical pump-driving ATPase (arsA); Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
       0.543
MJ_0670
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 37.37; identified by sequence similarity; putative.
 
    0.529
mdh
L-lactate dehydrogenase EGAD|7256|705; Catalyzes the reversible oxidation of (S)-malate and (S)- sulfolactate to oxaloacetate and sulfopyruvate, respectively. Can use both NADH and NADPH, although activity is higher with NADPH. Oxidation of (S)-sulfolactate is observed only in the presence of NADP(+). Can also oxidize tartrate. Cannot reduce pyruvate, nor alpha-ketoglutarate. Belongs to the LDH/MDH superfamily.
    
  0.514
MJ_1143
Conserved hypothetical protein; Large-conductance mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Selective for cations. Rectifies with voltage; Belongs to the MscS (TC 1.A.23) family.
       0.442
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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