node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cbiC | cbiD | MJ_0930 | MJ_0022 | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.998 |
cbiC | cbiE | MJ_0930 | MJ_1522 | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | Cobalamin biosynthesis precorrin-6Y methylase (cbiE); Catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8. | 0.999 |
cbiC | cbiF | MJ_0930 | MJ_1578 | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | Cobalamin biosynthesis precorrin-3 methylase (cbiF); Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A. | 0.995 |
cbiC | cbiG | MJ_0930 | MJ_1144 | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | Cobalamin biosynthesis protein (cbiG); Catalyzes the hydrolysis of the ring A acetate delta-lactone of cobalt-precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde. | 0.978 |
cbiC | cbiH | MJ_0930 | MJ_0813 | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | Cobalamin biosynthesis precorrin-3 methylase (cbiH); Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity). | 0.997 |
cbiC | cbiJ | MJ_0930 | MJ_0552 | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | Cobalamin biosynthesis protein (cbiJ); Catalyzes the reduction of the macrocycle of cobalt- precorrin-6A to cobalt-precorrin-6B. | 0.975 |
cbiC | cbiL | MJ_0930 | MJ_0771 | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.996 |
cbiC | cbiT | MJ_0930 | MJ_0391 | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | Cobalamin biosynthesis precorrin-8W decarboxylase (cbiT); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.991 |
cbiC | cbiX | MJ_0930 | MJ_0970 | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | Conserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.633 |
cbiC | cobA | MJ_0930 | MJ_0965 | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | uroporphyrin-III C-methyltransferase (cobA); Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin. | 0.859 |
cbiD | cbiC | MJ_0022 | MJ_0930 | Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | 0.998 |
cbiD | cbiE | MJ_0022 | MJ_1522 | Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalamin biosynthesis precorrin-6Y methylase (cbiE); Catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8. | 0.995 |
cbiD | cbiF | MJ_0022 | MJ_1578 | Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalamin biosynthesis precorrin-3 methylase (cbiF); Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A. | 0.947 |
cbiD | cbiG | MJ_0022 | MJ_1144 | Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalamin biosynthesis protein (cbiG); Catalyzes the hydrolysis of the ring A acetate delta-lactone of cobalt-precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde. | 0.999 |
cbiD | cbiH | MJ_0022 | MJ_0813 | Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalamin biosynthesis precorrin-3 methylase (cbiH); Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity). | 0.981 |
cbiD | cbiJ | MJ_0022 | MJ_0552 | Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalamin biosynthesis protein (cbiJ); Catalyzes the reduction of the macrocycle of cobalt- precorrin-6A to cobalt-precorrin-6B. | 0.997 |
cbiD | cbiL | MJ_0022 | MJ_0771 | Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.987 |
cbiD | cbiT | MJ_0022 | MJ_0391 | Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalamin biosynthesis precorrin-8W decarboxylase (cbiT); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.961 |
cbiD | cbiX | MJ_0022 | MJ_0970 | Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Conserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.817 |
cbiD | cobA | MJ_0022 | MJ_0965 | Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | uroporphyrin-III C-methyltransferase (cobA); Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin. | 0.848 |