Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
ribCRiboflavin synthase (ribC); Similar to GP:1419079 percent identity: 68.00; identified by sequence similarity; putative; Belongs to the DMRL synthase family. (156 aa)    
Predicted Functional Partners:
ribH
Riboflavin synthase beta chain (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.
 
  
 0.985
ribK
Conserved hypothetical protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). Can also utilize UTP as the phosphate donor, although less efficiently, and it is unclear if ATP and GTP can also serve as substrates or not.
    
  0.937
MJ_1183
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 39.60; identified by sequence similarity; putative; To M.thermoautotrophicum MTH862.
       0.912
ribB
GTP cyclohydrolase II (ribA); Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
 
   
 0.879
MJ_1182
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 30.59; identified by sequence similarity; putative.
       0.720
MJ_0959
Aspartate aminotransferase (aspC); Similar to PID:704449 GB:AE000666 percent identity: 54.69; identified by sequence similarity; putative.
       0.685
ribL
Glycerol-3-phosphate cytidyltransferase (taqD); Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. To a lesser extent, is also able to utilize other nucleotides such as CTP and GTP as substrates, producing the modified coenzymes, flavin cytosine dinucleotide (FCD) and flavin guanine dinucleotide (FGD), respectively. Does not catalyze the reverse reaction to produce FMN and ATP from FAD and PPi. Does not function as a glycerol-3- phosphate cytidylyltransferase, as previously annotated in the complete gen [...]
       0.685
MJ_0699
Atrazine chlorohydrolase isolog; Similar to GP:1493840 percent identity: 28.15; identified by sequence similarity; putative; Belongs to the metallo-dependent hydrolases superfamily.
 
     0.645
gch3
Conserved hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
       0.575
MJ_1416
Conserved hypothetical protein; Similar to GP:1707818 percent identity: 42.89; identified by sequence similarity; putative; Belongs to the HypE family.
  
     0.489
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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