STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pycBOxaloacetate decarboxylase alpha chain (oadA); Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (567 aa)    
Predicted Functional Partners:
pycA
Biotin carboxylase (accC); Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
 
 
 0.999
mdh
L-lactate dehydrogenase EGAD|7256|705; Catalyzes the reversible oxidation of (S)-malate and (S)- sulfolactate to oxaloacetate and sulfopyruvate, respectively. Can use both NADH and NADPH, although activity is higher with NADPH. Oxidation of (S)-sulfolactate is observed only in the presence of NADP(+). Can also oxidize tartrate. Cannot reduce pyruvate, nor alpha-ketoglutarate. Belongs to the LDH/MDH superfamily.
    
 0.956
ppsA
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
   
 
 0.928
MJ_0092
Heterodisulfide reductase, subunit D (hdrD); Similar to GP:1890198 percent identity: 31.87; identified by sequence similarity; putative; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
     
 0.925
MJ_0108
Pyruvate kinase; Similar to GB:D13095 SP:Q02499 GB:X57859 PID:285623 percent identity: 38.82; identified by sequence similarity; putative.
  
 
 0.925
korB
2-ketoglutarate ferredoxin oxidoreductase, subunit beta (korB); Similar to GB:X64521 PID:43499 percent identity: 40.43; identified by sequence similarity; putative.
  
 
 0.925
porC
Pyruvate ferredoxin oxidoreductase, subunit gamma (porG); Similar to PID:1197358 percent identity: 63.22; identified by sequence similarity; putative.
  
 
 0.923
porB
Pyruvate ferredoxin oxidoreductase, subunit beta (porB); Similar to PID:1197364 percent identity: 58.89; identified by sequence similarity; putative.
  
 
 0.921
porA
Pyruvate ferredoxin oxidoreductase, subunit alpha (porA); Similar to PID:1197363 percent identity: 57.33; identified by sequence similarity; putative.
    
 0.916
korA
2-ketoglutarate ferredoxin oxidoreductase, subunit alpha (korA); Similar to GB:X64521 PID:43498 percent identity: 44.24; identified by sequence similarity; putative.
    
 0.916
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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