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cofD protein (Methanocaldococcus jannaschii) - STRING interaction network
"cofD" - LPPG:FO 2-phospho-L-lactate transferase in Methanocaldococcus jannaschii
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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cofDLPPG-FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5’)guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP. To a lesser extent CofD also catalyzes a number of additional reactions that include the formation of FO-P, when the enzyme is incubated with FO and GDP, GTP, pyrophosphate, or tripolyphosphate and the hydrolysis of F420-0 to FO (311 aa)    
Predicted Functional Partners:
cofE
F420-0--gamma-glutamyl ligase; Catalyzes the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0- glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. Cannot use F420-2 as substrate to add more glutamates. Exhibits maximum activity with GTP, compared with UTP (66%) and dGTP (25%); with ATP, only F420-1 is observed as the product; CTP and TTP support no activity (249 aa)
 
 
  0.998
cofG
FO synthase subunit 1; Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (361 aa)
 
 
  0.997
cofH
FO synthase subunit 2; Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (359 aa)
 
 
  0.996
cofC
Hypothetical protein; Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5’-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Is able to utilize other purine nucleotides including dGTP and ITP as cosubstrates in place of GTP but with a lower activity. Does not display lactate kinase activity (224 aa)
 
   
  0.996
mtd
F420-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl- H(4)MPT(+) to methylene-H(4)MPT (277 aa)
       
  0.985
fno
Hypothetical protein; Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions (223 aa)
 
     
  0.923
fwdA
Formylmethanofuran dehydrogenase subunit FwdA (567 aa)
           
  0.881
MJ1255
Hypothetical protein (398 aa)
              0.876
mch
N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(+) (323 aa)
           
  0.860
MJ1257
Hypothetical protein (349 aa)
              0.859
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii, M. jannaschii DSM 2661, Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii, Methanococcus jannaschii DSM 2661
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