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cofD protein (Methanocaldococcus jannaschii) - STRING interaction network
"cofD" - 2-phospho-L-lactate transferase in Methanocaldococcus jannaschii
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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cofD2-phospho-L-lactate transferase; Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5’)guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP. To a lesser extent CofD also catalyzes a number of additional reactions that include the formation of FO-P, when the enzyme is incubated with FO and GDP, GTP, pyrophosphate, or tripolyphosphate and the hydrolysis of F420-0 to FO (311 aa)    
Predicted Functional Partners:
cofC
2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5’-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Is able to utilize other purine nucleotides including dGTP and ITP as cosubstrates in place of GTP but with a lower activity. Does not display lactate kinase activity (224 aa)
 
   
  0.999
cofE
Coenzyme F420-L-glutamate ligase; Catalyzes the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0- glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. Cannot use F420-2 as substrate to add more glutamates. Exhibits maximum activity with GTP, compared with UTP (66%) and dGTP (25%); with ATP, only F420-1 is observed as the product; CTP and TTP support no activity; Belongs to the CofE family (249 aa)
 
 
  0.998
cofH
FO synthase subunit 2; Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (359 aa)
 
   
  0.994
cofG
FO synthase subunit 1; Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (361 aa)
 
   
  0.971
MJ1255
Uncharacterized glycosyltransferase MJ1255; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1255; Belongs to the glycosyltransferase 28 family (398 aa)
   
        0.917
mtd
F420-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl- H(4)MPT(+) to methylene-H(4)MPT (277 aa)
   
   
    0.913
MJ1257
Uncharacterized protein MJ1257; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1257 (349 aa)
              0.849
MJ1254
Uncharacterized protein MJ1254; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1254 (469 aa)
              0.819
aksA
Probable homocitrate synthase AksA; Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)- homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate; Belongs to the alpha-IPM synthase/homocitrate synthase family (406 aa)
   
   
  0.761
aksF
Homoisocitrate dehydrogenase; Catalyzes the NAD-dependent oxidation and decarboxylation of (2R,3S)-homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate), (2R,3S)-homo(2)-isocitrate and (2R,3S)-homo(3)-isocitrate, into 2-oxoadipate, 2-oxopimelate, and 2-oxosuberate, respectively. This last compound is a precursor to coenzyme B and biotin in methanoarchaea. Is also able to produce 2-oxoazelate from (2R,3S)-homo(4)-isocitrate. Is not able to use NADP as an oxidant (347 aa)
   
   
  0.721
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii DSM2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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