| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MJ_0068 | MJ_0273 | MJ_0068 | MJ_0273 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 52.63; identified by sequence similarity; putative; Belongs to the UPF0212 family. | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0273. | 0.685 |
| MJ_0068 | MJ_0570 | MJ_0068 | MJ_0570 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 52.63; identified by sequence similarity; putative; Belongs to the UPF0212 family. | Conserved hypothetical protein; Similar to PID:1256896 PID:1256896 PID:1360566 percent identity: 35.35; identified by sequence similarity; putative. | 0.673 |
| MJ_0068 | dphB | MJ_0068 | MJ_1274 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 52.63; identified by sequence similarity; putative; Belongs to the UPF0212 family. | Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.667 |
| MJ_0068 | herA | MJ_0068 | MJ_1429 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 52.63; identified by sequence similarity; putative; Belongs to the UPF0212 family. | Conserved hypothetical protein; Involved in DNA double-strand break (DSB) repair (By similarity). Acts probably with NurA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Exhibits DNA-dependent ATPase activity and DNA helicase activity (By similarity); Belongs to the HerA family. | 0.685 |
| MJ_0273 | MJ_0068 | MJ_0273 | MJ_0068 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0273. | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 52.63; identified by sequence similarity; putative; Belongs to the UPF0212 family. | 0.685 |
| MJ_0273 | dphB | MJ_0273 | MJ_1274 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0273. | Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.685 |
| MJ_0273 | herA | MJ_0273 | MJ_1429 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0273. | Conserved hypothetical protein; Involved in DNA double-strand break (DSB) repair (By similarity). Acts probably with NurA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Exhibits DNA-dependent ATPase activity and DNA helicase activity (By similarity); Belongs to the HerA family. | 0.685 |
| MJ_0570 | MJ_0068 | MJ_0570 | MJ_0068 | Conserved hypothetical protein; Similar to PID:1256896 PID:1256896 PID:1360566 percent identity: 35.35; identified by sequence similarity; putative. | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 52.63; identified by sequence similarity; putative; Belongs to the UPF0212 family. | 0.673 |
| MJ_0570 | dph2 | MJ_0570 | MJ_0483 | Conserved hypothetical protein; Similar to PID:1256896 PID:1256896 PID:1360566 percent identity: 35.35; identified by sequence similarity; putative. | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.804 |
| MJ_0570 | dphB | MJ_0570 | MJ_1274 | Conserved hypothetical protein; Similar to PID:1256896 PID:1256896 PID:1360566 percent identity: 35.35; identified by sequence similarity; putative. | Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.929 |
| MJ_0570 | fusA | MJ_0570 | MJ_1048 | Conserved hypothetical protein; Similar to PID:1256896 PID:1256896 PID:1360566 percent identity: 35.35; identified by sequence similarity; putative. | Translation elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase [...] | 0.938 |
| MJ_1275 | dphB | MJ_1275 | MJ_1274 | NA(+)/H(+) antiporter (napA); This is probably a Na(+)/H(+) antiporter; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.608 |
| dph2 | MJ_0570 | MJ_0483 | MJ_0570 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Conserved hypothetical protein; Similar to PID:1256896 PID:1256896 PID:1360566 percent identity: 35.35; identified by sequence similarity; putative. | 0.804 |
| dph2 | dphB | MJ_0483 | MJ_1274 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.957 |
| dph2 | fusA | MJ_0483 | MJ_1048 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase [...] | 0.984 |
| dph2 | rpl37ae | MJ_0483 | MJ_0593 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | LSU ribosomal protein L37AE; Binds to the 23S rRNA. | 0.718 |
| dphB | MJ_0068 | MJ_1274 | MJ_0068 | Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 52.63; identified by sequence similarity; putative; Belongs to the UPF0212 family. | 0.667 |
| dphB | MJ_0273 | MJ_1274 | MJ_0273 | Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0273. | 0.685 |
| dphB | MJ_0570 | MJ_1274 | MJ_0570 | Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | Conserved hypothetical protein; Similar to PID:1256896 PID:1256896 PID:1360566 percent identity: 35.35; identified by sequence similarity; putative. | 0.929 |
| dphB | MJ_1275 | MJ_1274 | MJ_1275 | Diphthine synthase (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | NA(+)/H(+) antiporter (napA); This is probably a Na(+)/H(+) antiporter; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.608 |
