STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bioBBiotin synthetase (bioB); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (358 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthetase (bioD); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.996
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (bioA); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
  
 0.992
MJ_0830
Conserved hypothetical protein; Similar to PID:1652988 percent identity: 29.67; identified by sequence similarity; putative; Belongs to the LarE family.
  
    0.941
MJ_1619
Biotin operon repressor/biotin--[acetyl-CoA-carboxylase] ligase (birA); Similar to GB:L42023 SP:P46363 PID:1161402 PID:1222142 PID:1204478 percent identity: 29.41; identified by sequence similarity; putative.
  
 
 0.931
bioF
8-amino-7-oxononanoate synthase (bioF); Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
 
  
 0.930
MJ_0785
Biotin synthetase, putative (bioB); Similar to GB:M27867 SP:P19206 PID:142591 PID:520750 percent identity: 27.43; identified by sequence similarity; putative.
  
  
 
0.925
bioW
6-carboxyhexanoate-CoA ligase (bioW); Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
 
  
 0.901
argD
Acetylornithine aminotransferase (argD); Similar to GB:X78854 PID:580729 SP:P54752 percent identity: 46.37; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
 
  
 0.849
MJ_0670
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 37.37; identified by sequence similarity; putative.
   
    0.816
MJ_0871
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 39.58; identified by sequence similarity; putative.
   
    0.772
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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