Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
bioW6-carboxyhexanoate-CoA ligase (bioW); Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP. (237 aa)    
Predicted Functional Partners:
bioF
8-amino-7-oxononanoate synthase (bioF); Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
 
 0.999
bioD
Dethiobiotin synthetase (bioD); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
  
 0.962
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (bioA); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
 
  
 0.915
bioB
Biotin synthetase (bioB); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
  
 0.899
MJ_0597
Conserved hypothetical protein; Similar to PID:747640 GB:AE000666 percent identity: 24.23; identified by sequence similarity; putative.
  
  
 0.719
MJ_0785
Biotin synthetase, putative (bioB); Similar to GB:M27867 SP:P19206 PID:142591 PID:520750 percent identity: 27.43; identified by sequence similarity; putative.
  
  
 0.719
MJ_1294
Tartrate dehydratase, subunit alpha (ttdA); Similar to GB:L14781 SP:P05847 PID:347084 PID:882584 PID:1789442 percent identity: 32.86; identified by sequence similarity; putative.
       0.558
MJ_1295
Conserved hypothetical protein; Similar to GP:1787520 percent identity: 31.95; identified by sequence similarity; putative.
       0.554
MJ_0826
Conserved hypothetical protein; Similar to GP:1786696 percent identity: 24.82; identified by sequence similarity; putative.
  
     0.452
MJ_0201
Lipoprotein B (lppB); Similar to GB:L42023 SP:P44832 PID:1005617 PID:1220788 PID:1204952 percent identity: 27.82; identified by sequence similarity; putative.
 
     0.414
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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