STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_1315Conserved hypothetical protein; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA (By similarity). (361 aa)    
Predicted Functional Partners:
MJ_1313
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 55.44; identified by sequence similarity; putative; To M.thermoautotrophicum MTH1421.
       0.927
cobD
Cobalamin biosynthesis protein B (cbiB); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
       0.927
MJ_0047
Putative mRNA 3'-end processing factor 1; Similar to GP:1707412 percent identity: 30.64; identified by sequence similarity; putative; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family.
   
 0.913
MJ_0162
Putative mRNA 3'-end processing factor 3; Similar to GP:1707412 percent identity: 35.48; identified by sequence similarity; putative; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family.
   
 0.913
endA
tRNA intron endonuclease (endA); Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
  
 
 0.837
MJ_1316
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 38.46; identified by sequence similarity; putative; Belongs to the UPF0248 family.
       0.778
MJ_1312
Conserved hypothetical protein; Similar to GP:1653753 percent identity: 33.00; identified by sequence similarity; putative.
       0.726
rtcB
Conserved hypothetical protein; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends; Belongs to the RtcB family.
      
 0.663
flpA
Fibrillarin (fib); Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
  
 
 0.554
MJ_1559
Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency (By similarity); Belongs to the THEP1 NTPase family.
  
     0.550
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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