STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnAGlutamine synthetase (glnA); Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Beta-glutamate is a much poorer substrate than alpha-glutamate. (454 aa)    
Predicted Functional Partners:
nifH
Nitrogenase iron protein (nifH); The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
  
 
 0.984
glmS
Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) (glmS); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
 
 
 0.983
carA
Carbamoyl-phosphate synthase, small (or glutamine) subunit (carA); Similar to GB:M59757 SP:P25993 PID:143389 GB:AL009126 percent identity: 48.55; identified by sequence similarity; putative; Belongs to the CarA family.
  
 
 0.957
purF
Amidophosphoribosyltransferase (purF); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
    
 0.932
carB1
Carbamoyl-phosphate synthase, medium subunit (carB1); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 53.32; identified by sequence similarity; putative; Belongs to the CarB family.
  
 
 0.930
carB2
Carbamoyl-phosphate synthase, large subunit (carB2); Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464 percent identity: 52.95; identified by sequence similarity; putative; Belongs to the CarB family.
  
 
 0.930
hcp
[6Fe-6S] prismane-containing protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
    
 0.924
MJ_1351
Glutamate synthase (gltB); Similar to GB:M18747 SP:P09831 GB:L20253 GB:M33743 GB:M68876 percent identity: 40.46; identified by sequence similarity; putative; Belongs to the glutamate synthase family.
  
  
 0.918
nrpR
Conserved hypothetical protein; Transcriptional repressor of nitrogen fixation and assimilation genes. Binds to two tandem operators in the glnA and nif promoters, thereby blocking transcription of the genes. Belongs to the NrpR family.
     
 0.917
purQ
Phosphoribosylformylglycinamidine synthase I, (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...]
    
 0.916
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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