Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MJ_1365Pheromone shutdown protein (traB); Similar to GB:U00681 PID:388268 PID:475428 percent identity: 30.39; identified by sequence similarity; putative. (397 aa)    
Predicted Functional Partners:
truD2
Conserved hypothetical protein; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family.
 
     0.877
MJ_0392
Conserved hypothetical protein; A site-2 regulated intramembrane protease (S2P) that cleaves type-2 transmembrane proteins within their membrane-spanning domains; its endogenous substrate is unknown. Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this enzyme), while cytoplasmic proteases finish degr [...]
     
 0.691
MJ_0611
Conserved hypothetical integral membrane protein; Similar to GP:1565238 percent identity: 34.56; identified by sequence similarity; putative; Belongs to the peptidase M50B family.
       0.685
rnz
Conserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.
       0.685
purM
Phosphoribosylformylglycinamidine cyclo-ligase (purM); Similar to GB:J02732 SP:P12043 PID:143371 GB:AL009126 percent identity: 39.76; identified by sequence similarity; putative.
       0.676
rnhB
Ribonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
   
   0.661
MJ_0033
Succinate dehydrogenase, flavoprotein subunit (sdhA); Similar to GP:1524302 percent identity: 41.63; identified by sequence similarity; putative.
    
   0.651
MJ_1302
Photosystem I iron-sulfur center 1 isolog; Identified by sequence similarity; putative.
    
   0.651
comB
Conserved hypothetical protein; Hydrolyzes both enantiomers of 2-phosphosulfolactate. Able to hydrolyze both enantiomers of 2-hydroxycarboxylic acids with pseudosymmetric centers of inversion. Specifically hydrolyzes (S)- phospholactate and (S)-phosphoglycerate.
       0.642
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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